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This success has concerned the biomedical world as well, where melt-based methods represent the golden standard to produce scaffolds for hard-tissue engineering. Despite the large number of studies present in the literature on scaffold production, the fabrication process is still affected by drawbacks and limitations, which hinders the standardization and upscaling to the industrial level. In this review, we briefly present the history of additive manufacturing and the reasons of its success, with particular reference to the tissue engineering and regenerative medicine world. We then proceed to highlight the current factors limiting the straightforwardness of the production process and affecting the quality and the performance of the manufactured scaffolds. Eventually, we suggest potential strategies to increase the level of control during manufacturing and to improve the biomimicry of the fabricated constructs, with the goal of obtaining a more optimal workflow.<\/jats:p>","DOI":"10.1089\/3dp.2023.0104","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T18:16:46Z","timestamp":1721240206000},"page":"499-517","source":"Crossref","is-referenced-by-count":4,"title":["Melt-Extrusion Additive Manufacturing for Tissue Engineering: Applications and Limitations"],"prefix":"10.1177","volume":"12","author":[{"given":"Andrea Roberto","family":"Calore","sequence":"first","affiliation":[{"name":"MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, The Netherlands."},{"name":"Aachen-Maastricht Institute for Biobased Materials (AMIBM), Maastricht University, Geleen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1263-9250","authenticated-orcid":false,"given":"Carlos","family":"Mota","sequence":"additional","affiliation":[{"name":"MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Bernaerts","sequence":"additional","affiliation":[{"name":"Aachen-Maastricht Institute for Biobased Materials (AMIBM), Maastricht University, Geleen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules","family":"Harings","sequence":"additional","affiliation":[{"name":"Aachen-Maastricht Institute for Biobased Materials (AMIBM), Maastricht University, Geleen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1298-6025","authenticated-orcid":false,"given":"Lorenzo","family":"Moroni","sequence":"additional","affiliation":[{"name":"MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000690"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.2307\/3562262"},{"key":"e_1_3_4_4_2","unstructured":"Ministero della Salute. 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