{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:18:37Z","timestamp":1777519117687,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Medical Acupuncture"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Ear acupuncture, as a system for treating and preventing diseases through stimulation of points on the auricle, has been systematically introduced during the last 60 years. Although the auricular cartography was described somatotopically as an inverted fetus by Paul Nogier, MD, the underlying mechanism of auricular stimulation remains unclear. The aim of this research was to gain an understanding of the structural basis of auricular stimulation, as well as showing the distribution of the nerve fibers, and the blood and lymphatic vessels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The distribution of nerve fibers, and blood and lymphatic vessels was examined in whole-mount auricular skins of mice by combining the biomarkers protein gene product 9.5, cluster of differentiation 31, and lymphatic-vessel endothelial hyaluronan receptor\u20131 following tissue-clearing treatment with multiple immunofluorescent staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The labeled nerve fibers, and the blood and lymphatic vessels were distributed extensively in the inner and outer parts of the auricular skin. Auricular nerves aligning with blood vessels ran from the basal region to the peripheral region and crossed over lymphatic vessels, thus forming the neural, vascular, and lymphatic networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>As these are important tissue components of auricular skin, this result implies that the auricular nerve fibers, and blood and lymphatic vessels may coordinate with each other to respond directly to auricular stimulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/acu.2023.0077","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T14:10:21Z","timestamp":1707142221000},"page":"79-86","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Networks of Nerve Fibers, and Blood and Lymphatic Vessels in the Mouse Auricle: The Structural Basis of Ear Acupuncture"],"prefix":"10.1177","volume":"36","author":[{"given":"Yuqing","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Su","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Cui","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihan","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanzhu","family":"Bai","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/acu.2014.1038"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/495684"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/acu.2019.1349"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/acu.2021.0075"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7830919"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2018.03.018"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2019.00421"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/joa.13122"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2022.103038"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18581-7"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12550"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21395"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29839-z"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2020.00022"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8712-2_17"},{"issue":"6","key":"e_1_3_4_17_2","first-page":"1473","article-title":"Tissue clearing for three-dimensional visualization of the auricular neurovascular network","volume":"50","author":"Zhang KW","year":"2023","unstructured":"Zhang KW, , Guo YT, , Su YX, et al. 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