{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:24:13Z","timestamp":1777526653931,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASSAY and Drug Development Technologies"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1089\/adt.2010.0350","type":"journal-article","created":{"date-parts":[[2011,5,11]],"date-time":"2011-05-11T19:51:26Z","timestamp":1305143486000},"page":"487-495","source":"Crossref","is-referenced-by-count":8,"title":["A Facilitated Approach to Evaluate the Inhibitor Mode and Potency of Compounds Targeting Microsomal Prostaglandin E Synthase-1"],"prefix":"10.1177","volume":"9","author":[{"given":"Linda","family":"Spahiu","sequence":"first","affiliation":[{"name":"Actar AB, Solna, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patric","family":"Stenberg","sequence":"additional","affiliation":[{"name":"Actar AB, Solna, Sweden."},{"name":"NovaSAID AB, Solna, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Larsson","sequence":"additional","affiliation":[{"name":"Actar AB, Solna, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Wannberg","sequence":"additional","affiliation":[{"name":"Actar AB, Solna, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Alterman","sequence":"additional","affiliation":[{"name":"Actar AB, Solna, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Kull","sequence":"additional","affiliation":[{"name":"Actar AB, Solna, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Nekhotiaeva","sequence":"additional","affiliation":[{"name":"Actar AB, Solna, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Morgenstern","sequence":"additional","affiliation":[{"name":"Actar AB, Solna, Sweden."},{"name":"NovaSAID AB, Solna, Sweden."},{"name":"Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.3.3"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(91)90054-P"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1126\/science.294.5548.1871"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1021\/bi700605m"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(80)90127-6"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(80)90126-4"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003504200"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003505200"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1124\/pr.59.3.1"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.07.014"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-5-62"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/path.1907"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604400103"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611468104"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.142182"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00239.2003"},{"key":"B17","first-page":"4872","volume":"63","author":"Takeda H","year":"2003","journal-title":"Cancer Res"},{"key":"B18","first-page":"104","volume":"1766","author":"Chell S","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M700602-JLR200"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20500"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2007.10.015"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303227200"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-5928(02)00566-1"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.01.010"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.05.056"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/nature06009"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/nature05936"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1126\/science.1144346"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2008.41.11.808"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-008-9233-4"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802894105"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.138776"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.114454"},{"key":"B34","first-page":"658","volume":"9","author":"Basevich VV","year":"1983","journal-title":"Bioorg Khim"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(66)90167-9"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1968.tb00428.x"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/0471220639"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(91)90007-M"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2006.07.007"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3570263"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.05.027"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(94)00239-D"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1177\/1087057108328763"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00176-8"}],"container-title":["ASSAY and Drug Development Technologies"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/adt.2010.0350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:30:32Z","timestamp":1777393832000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/adt.2010.0350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1089\/adt.2010.0350"],"URL":"https:\/\/doi.org\/10.1089\/adt.2010.0350","relation":{},"ISSN":["1540-658X","1557-8127"],"issn-type":[{"value":"1540-658X","type":"print"},{"value":"1557-8127","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}