{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T12:29:51Z","timestamp":1785587391003,"version":"3.56.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["ASSAY and Drug Development Technologies"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>\n                    Due to the increasing resistance of various\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    species to azole drugs, particularly fluconazole, it would be of significant importance to look for alternative therapies. The aim of this study was to investigate the antifungal activity of capric acid and its\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    interactions with nystatin and fluconazole against\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    isolates. A total of 40\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    isolates (\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    , 36;\n                    <jats:italic toggle=\"yes\">C. kefyr<\/jats:italic>\n                    , 2;\n                    <jats:italic toggle=\"yes\">C. tropicalis<\/jats:italic>\n                    , 1;\n                    <jats:italic toggle=\"yes\">C. glabrata<\/jats:italic>\n                    , 1) collected from the oral cavity of neonates with oropharyngeal candidiasis and a reference strain of\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    (ATCC 10231) were used in this study. Antifungal activity of capric acid and two comparator antifungal drugs, namely fluconazole and nystatin, was tested according to CLSI M27-A3\/M60 method. The\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    interaction between capric acid with fluconazole and nystatin was determined following a checkerboard method and results were interpreted using fractional inhibitory concentration index. Nystatin had the lowest minimum inhibitory concentrations (range, 0.125\u20138\u2009\u03bcg\/mL; geometric mean [GM], 0.6229\u2009\u03bcg\/mL) followed by fluconazole (range, 0.5\u201316\u2009\u03bcg\/mL; GM, 1.9011\u2009\u03bcg\/mL) and capric acid (range, 128\u20132,048\u2009\u03bcg\/mL; GM, 835.9756\u2009\u03bcg\/mL). When tested in combination, capric acid with fluconazole demonstrated synergistic, indifferent, and antagonistic interactions in 3 (7.317%), 24 (58.536%), and 14 (34.146%) cases, respectively. For combination of capric acid with nystatin, synergistic, indifferent, and antagonistic interactions were observed in 1 (2.439%), 19 (46.341%), and 21 (51.219%) cases, respectively. All cases of synergistic interactions were against resistant or susceptible dose-dependent isolates. Fluconazole, nystatin, and capric acid seem to be more effective when they are used alone compared with their combination. However, their combination might be effective on resistant isolates.\n                  <\/jats:p>","DOI":"10.1089\/adt.2020.971","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T18:47:21Z","timestamp":1589222841000},"page":"195-201","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Antifungal Activity of Capric Acid, Nystatin, and Fluconazole and Their\n                    <i>In Vitro<\/i>\n                    Interactions Against\n                    <i>Candida<\/i>\n                    Isolates from Neonatal Oral Thrush"],"prefix":"10.1177","volume":"18","author":[{"given":"Halala","family":"Khalandi","sequence":"first","affiliation":[{"name":"Department of Medical Parasitology and Mycology, School of Medicine, Iran University of Medical Science, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Masoori","sequence":"additional","affiliation":[{"name":"Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran."},{"name":"Department of Laboratory Sciences, School of Allied Medical Sciences, Lorestan University of Medical Sciences, Khorramabad, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Farahyar","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Mycology, School of Medicine, Iran University of Medical Science, Tehran, Iran."},{"name":"Microbial Biotechnology Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Akbar","family":"Delbandi","sequence":"additional","affiliation":[{"name":"Immunology Research Center, Immunology and Infectious Disease Institute, Iran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Raiesi","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran."},{"name":"Department of Parasitology, School of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Farzanegan","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Mycology, Guilan University of Medical Science, Anzali International Campus, Guilan, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghafour","family":"Khalandi","sequence":"additional","affiliation":[{"name":"Faculty of Physics, University of Tabriz, Tabriz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahram","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Mycology, School of Medicine, Iran University of Medical Science, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayebeh","family":"Erfanirad","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Mycology, School of Medicine, Iran University of Medical Science, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehraban","family":"Falahati","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Mycology, School of Medicine, Iran University of Medical Science, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"419","article-title":"The frequency of oral candidal infection in Kerman dental clinics","volume":"23","author":"Chamani G","year":"2005","unstructured":"Chamani G, , Derhami A, , Zarei M, , Rad M: The frequency of oral candidal infection in Kerman dental clinics. 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