{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:27:18Z","timestamp":1789918038875,"version":"4.0.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1988,2,1]],"date-time":"1988-02-01T00:00:00Z","timestamp":570672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[1988,2]]},"abstract":"<jats:p>\n                    A transregulatory gene,\n                    <jats:italic toggle=\"yes\">trs<\/jats:italic>\n                    , of human immunodeficiency virus I (HIV-1) was expressed in bacteria as a 26-kD fusion protein. Survey of over 100 individuals infected with HIV revealed a nonrandom distribution of seropositivity against\n                    <jats:italic toggle=\"yes\">trs<\/jats:italic>\n                    : a few of the asymptomatic carriers and AIDS patients (less than 5%) had sera that reacted with the 26-kD protein. In contrast, 29% of the ARC patients' sera reacted positively. This result is different from those of serological reactivities of the other accessory gene products of HIV-1 (\n                    <jats:italic toggle=\"yes\">tat, sor<\/jats:italic>\n                    , 3\u2032\n                    <jats:italic toggle=\"yes\">orf<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">R<\/jats:italic>\n                    ) which did not differentiate among stages of clinical progression. Since ARC is a prodrome for full-blown AIDS, these results suggest that\n                    <jats:italic toggle=\"yes\">trs<\/jats:italic>\n                    may be useful as a prognostic marker for AIDS development.\n                  <\/jats:p>","DOI":"10.1089\/aid.1988.4.11","type":"journal-article","created":{"date-parts":[[2009,3,16]],"date-time":"2009-03-16T10:39:42Z","timestamp":1237199982000},"page":"11-16","source":"Crossref","is-referenced-by-count":9,"title":["Nonrandom Distribution of Antibodies to the TRS Protein of Human Immunodeficiency Virus in Infected People with Different Clinical Status"],"prefix":"10.1177","volume":"4","author":[{"given":"Pranab K.","family":"Chanda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Ghrayeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flossie","family":"Wong-Staal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1988,2,1]]},"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.1988.4.11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.1988.4.11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T07:10:36Z","timestamp":1775113836000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/aid.1988.4.11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,2]]}},"alternative-id":["10.1089\/aid.1988.4.11"],"URL":"https:\/\/doi.org\/10.1089\/aid.1988.4.11","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,2]]}}}