{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:29:40Z","timestamp":1774672180602,"version":"3.50.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1991,3,1]],"date-time":"1991-03-01T00:00:00Z","timestamp":667785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[1991,3]]},"abstract":"<jats:p>\n                    In a preliminary study, two of four rabbits infected with human T-cell leukemia virus type I (HTLV-I) demonstrated prolonged primary chancres following super infection with\n                    <jats:italic toggle=\"yes\">Treponema pallidum<\/jats:italic>\n                    , the causative agent of syphilis. Two rabbits inoculated with 1 X 10\n                    <jats:sup>7<\/jats:sup>\n                    HTLV-I-infected human MT-2 cells and two with infected rabbit cells from a line established in this laboratory (RLT-P), developed latent HTLV-I infection as detected by seroconversion 10 weeks after infection and by detection of HTLV-I sequences in the DNA of peripheral blood lymphocytes after amplification by polymerase chair reaction (PCR) 15 weeks after infection. The rabbits remained clinically normal and had normal blood counts. Six months after infection, the four HTLV-infected rabbits and two noninfected controls were challenged by the intradermal inoculation of 1 X 10\n                    <jats:sup>6<\/jats:sup>\n                    <jats:italic toggle=\"yes\">Treponema pallidum<\/jats:italic>\n                    into eight sites on the shaved back. The lesions of two of the HTLV-I-infected rabbits had a time course similar to non-HTLV-I-infected controls and were completely healed by 4 weeks. The lesions of one of the other two rabbits with progressive disease began to heal about 7 weeks after\n                    <jats:italic toggle=\"yes\">T. pallidum<\/jats:italic>\n                    challenge. The cutaneous lesions in the other rabbit remained dark-field positive and became a confluent eschar at 8 weeks; healing only after treatment with penicillin. Four months after the primary challenge none of the six rabbits previously challenged with\n                    <jats:italic toggle=\"yes\">T. pallidum<\/jats:italic>\n                    had developed lesions after rechallenge and thus expressed chancre immunity. These results demonstrate that rabbits with latent HTLV-I infections may have defective cell-mediated immunity.\n                  <\/jats:p>","DOI":"10.1089\/aid.1991.7.323","type":"journal-article","created":{"date-parts":[[2009,3,16]],"date-time":"2009-03-16T12:06:42Z","timestamp":1237205202000},"page":"323-331","source":"Crossref","is-referenced-by-count":5,"title":["Protracted\n                    <i>Treponema pallidum<\/i>\n                    -Induced Cutaneous Chancres in Rabbits Infected with Human T-Cell Leukemia Virus Type I"],"prefix":"10.1177","volume":"7","author":[{"given":"Chien-Te Kent","family":"Tseng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stewart","family":"Sell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,3,1]]},"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.1991.7.323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.1991.7.323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:19:03Z","timestamp":1774624743000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/aid.1991.7.323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,3]]}},"alternative-id":["10.1089\/aid.1991.7.323"],"URL":"https:\/\/doi.org\/10.1089\/aid.1991.7.323","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,3]]}}}