{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:30:49Z","timestamp":1789587049367,"version":"build-2803163510"},"reference-count":0,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[1993,10,1]],"date-time":"1993-10-01T00:00:00Z","timestamp":749433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">ets<\/jats:italic>\n                    is a multigene family and its members share a common ETS DNA-binding domain. ETS proteins activate transcription via binding to a purine-rich GGAA core sequence located in promoters\/enhancers of various genes, including several that are transcriptionally active in T cells. The\n                    <jats:italic toggle=\"yes\">ETS<\/jats:italic>\n                    1,\n                    <jats:italic toggle=\"yes\">ETS<\/jats:italic>\n                    2, and\n                    <jats:italic toggle=\"yes\">ERBG<\/jats:italic>\n                    \/Hu-\n                    <jats:italic toggle=\"yes\">FLI<\/jats:italic>\n                    -1 gene expression pattern also suggests a role for these genes in cells of hematopoietic lineage. The HIV-1 LTR core enhancer contains two 10-base pair direct repeat sequences (left and right) that are required for regulation of HIV-1 mRNA expression by host transcription factors, including NF\n                    <jats:italic toggle=\"yes\">k<\/jats:italic>\n                    B. Two ETS-binding sites are present in the core enhancer of all the HIV-1 isolates reported so far. In our studies, we utilized HIV-1 HXB2 and HIV-1 Z2Z6 core enhancers because the Z2Z6 strain has a single point mutation flanking the right ETS-binding site. We demonstrate that the ETS1, ETS2, and ERGB\/Hu-FLI-1 proteins can trans-activate transcription from both the HXB2 and Z2Z6 core enhancer when linked to a reporter (\n                    <jats:italic toggle=\"yes\">cat<\/jats:italic>\n                    ) gene. In addition, we show that the DNA binding and trans-activation with the Z2Z6 core enhancer is at least 40-fold higher than that observed with the HXB2 core enhancer. Further, we provide evidence that the marked increase in binding and trans-activation with Z2Z6 core enhancer sequences is due to the substitution of a flanking T residue in HXB2 TGG AA) by a C residue in Z2Z6 (CGGAA) isolate, thus generating an optimal ETS-binding core (CGGAA) sequence.\n                  <\/jats:p>","DOI":"10.1089\/aid.1993.9.1017","type":"journal-article","created":{"date-parts":[[2009,3,16]],"date-time":"2009-03-16T13:19:11Z","timestamp":1237209551000},"page":"1017-1023","source":"Crossref","is-referenced-by-count":35,"title":["ETS Family Proteins Activate Transcription from HIV-1 Long Terminal Repeat"],"prefix":"10.1177","volume":"9","author":[{"given":"Arun","family":"Seth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Hodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delores M.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Panayiotakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis K.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takis S.","family":"Papas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1993,10,1]]},"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.1993.9.1017","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.1993.9.1017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:45:18Z","timestamp":1774626318000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/aid.1993.9.1017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1993,10]]}},"alternative-id":["10.1089\/aid.1993.9.1017"],"URL":"https:\/\/doi.org\/10.1089\/aid.1993.9.1017","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,10]]}}}