{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T16:17:12Z","timestamp":1774628232025,"version":"3.50.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1993,2,1]],"date-time":"1993-02-01T00:00:00Z","timestamp":728524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[1993,2]]},"abstract":"<jats:p>\n                    Human T-cell leukemia virus type I (HTLV-I) has been associated with adult T-cell leukemia\/lymphoma and the chronic neurologic disorder tropical spastic paraparesis\/HTLV-I-associated myelopathy (TSP\/HAM). To study the genetic structure of the virus associated with TSP\/HAM, we have obtained and sequenced a partial genomic clone from an HTLV-I-positive cell line established from cerebrospinal fluid (CSF) of a Jamaican patient with TSP\/HAM. This clone consisted of a 4.3-kb viral sequence containing the 5\u2032 long terminal repeat (LTR),\n                    <jats:italic toggle=\"yes\">gag<\/jats:italic>\n                    , and N-terminal portion of the\n                    <jats:italic toggle=\"yes\">pol<\/jats:italic>\n                    gene, with an overall 1.3% sequence variation resulting from mostly nucleotide substitutions, as compared to the prototype HTLV-I ATK-1. The\n                    <jats:italic toggle=\"yes\">gag<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">pol<\/jats:italic>\n                    regions showed only 1.4% and 1.2% nucleotide variations, respectively. However, the U3 region of the LTR showed the highest sequence variation (3.6%), where several changes appear to be common among certain TSP\/HAM isolates. Several of these changes reside within the 21-bp boundaries and the Tax-responsive element. It would be important to determine if the observed changes are sufficient to cause neurologic disorders similar to the murine leukemia virus system or simply reflect the divergent pool of HTLV-I from different geographic locations. At this time, we cannot rule out the possibility that the observed changes have either direct or indirect significance for the HTLV-I pathogenesis in TSP\/HAM.\n                  <\/jats:p>","DOI":"10.1089\/aid.1993.9.109","type":"journal-article","created":{"date-parts":[[2009,3,16]],"date-time":"2009-03-16T13:50:24Z","timestamp":1237211424000},"page":"109-114","source":"Crossref","is-referenced-by-count":16,"title":["Nucleotide Sequence Analysis of HTLV-I Isolated from Cerebrospinal Fluid of a Patient with TSP\/HAM: Comparison to Other HTLV-I Isolates"],"prefix":"10.1177","volume":"9","author":[{"given":"Robin","family":"Mukhopadhyaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Reza","family":"Sadaie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,2,1]]},"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.1993.9.109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.1993.9.109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:41:26Z","timestamp":1774626086000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/aid.1993.9.109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,2]]}},"alternative-id":["10.1089\/aid.1993.9.109"],"URL":"https:\/\/doi.org\/10.1089\/aid.1993.9.109","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,2]]}}}