{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:44:46Z","timestamp":1774626286799,"version":"3.50.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1994,3,1]],"date-time":"1994-03-01T00:00:00Z","timestamp":762480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[1994,3]]},"abstract":"<jats:p>\n                    The possibility of a retroviral etiology has long been raised in a number of autoimmune disorders. More recently, Sj\u00f6gren's syndrome and rheumatoid arthritis were noted in transgenic mice carrying the\n                    <jats:italic toggle=\"yes\">tax<\/jats:italic>\n                    gene of human T cell leukemia virus type I (HTLV-I). To evaluate the involvement of HTLV-I Tax in autoimmunity, its effect on expression of autoantigens was investigated. A metallothionein promoter-driven p40\n                    <jats:sup>\n                      <jats:italic toggle=\"yes\">tax<\/jats:italic>\n                    <\/jats:sup>\n                    expression plasmid, pMAXRHneo-1, was stably transfected into Molt4 and Jurkat cells and the p40\n                    <jats:sup>\n                      <jats:italic toggle=\"yes\">tax<\/jats:italic>\n                    <\/jats:sup>\n                    protein was induced with CdCl2.\n                    <jats:italic toggle=\"yes\">trans<\/jats:italic>\n                    -Activation or\n                    <jats:italic toggle=\"yes\">trans<\/jats:italic>\n                    -repression of autoantigens by HTLV-I Tax was studied by Western blot analysis utilizing autoantigen-specific murine monoclonal and rabbit polyvalent antibodies as well as sera from 161 autoimmune patients. Induction of p40\n                    <jats:sup>\n                      <jats:italic toggle=\"yes\">tax<\/jats:italic>\n                    <\/jats:sup>\n                    of HTLV-I had no significant effect on levels of expression of common autoantigens Ul snRNP, Sm, Ro, La, HSP-70, topoisomerase I\/Scl70, PCNA, and HRES-1. Expression of two potentially novel autoantigens, 44 and 46 kDa, was induced by p40\n                    <jats:sup>\n                      <jats:italic toggle=\"yes\">tax<\/jats:italic>\n                    <\/jats:sup>\n                    as detected by sera of progressive systemic sclerosis patients, BAK and VAR. By contrast, expression of 24- and 34-kDa proteins was suppressed in response to induction of p40\n                    <jats:sup>\n                      <jats:italic toggle=\"yes\">tax<\/jats:italic>\n                    <\/jats:sup>\n                    as detected by sera of systemic lupus erythematosus patients PUS and HOR. Because none of these patients were infected by HTLV-I, a protein functionally similar to p40\n                    <jats:sup>\n                      <jats:italic toggle=\"yes\">tax<\/jats:italic>\n                    <\/jats:sup>\n                    may be involved in eliciting autoantigen expression and a subsequent autoantibody response in a minority of patients with PSS and SLE. Sera of autoimmune patients may also be utilized to detect novel proteins\n                    <jats:italic toggle=\"yes\">trans<\/jats:italic>\n                    -activated or trans-repressed by p40\n                    <jats:sup>\n                      <jats:italic toggle=\"yes\">tax<\/jats:italic>\n                    <\/jats:sup>\n                    of HTLV-I.\n                  <\/jats:p>","DOI":"10.1089\/aid.1994.10.303","type":"journal-article","created":{"date-parts":[[2009,3,16]],"date-time":"2009-03-16T14:40:31Z","timestamp":1237214431000},"page":"303-308","source":"Crossref","is-referenced-by-count":5,"title":["Effect of p40\n                    <sup>tax<\/sup>\n                    <i>trans<\/i>\n                    -Activator of Human T Cell Lymphotropic Virus Type I on Expression of Autoantigens"],"prefix":"10.1177","volume":"10","author":[{"given":"Katalin","family":"Banki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Ablonczy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andras","family":"Perl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,3,1]]},"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.1994.10.303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.1994.10.303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:23:14Z","timestamp":1774621394000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/aid.1994.10.303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,3]]}},"alternative-id":["10.1089\/aid.1994.10.303"],"URL":"https:\/\/doi.org\/10.1089\/aid.1994.10.303","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3]]}}}