{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:42:21Z","timestamp":1790048541433,"version":"4.0.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1994,6,1]],"date-time":"1994-06-01T00:00:00Z","timestamp":770428800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:p>\n                    Data indicate the presence in the Seychelles Islands of a high level of human T cell leukemia\/lymphoma virus type I (HTLV-I) endemicity as well as the presence of tropical spastic paraparesis\/HTLV-I-associated myelopathy (TSP\/HAM). We present here the results of an hospital survey performed since 1988 in La R\u00e9union Island, located in the Indian Ocean southeast of the Seychelles archipelago, aimed at evaluating HTLV-I endemicity, detecting HTLV-I-associated diseases, and characterizing viral isolates. Seven individuals were found to have HTLV-I-specific antibodies in their sera. These include 3 of 257 patients from St. Pierre Hospital, 1 of them exhibiting a typical clinical feature of TSP\/HAM (the first described case in this region), 1 blood donor of 3900, and 3 relatives. A further nine individuals exhibiting only \"\n                    <jats:italic toggle=\"yes\">gag<\/jats:italic>\n                    -encoded proteins\" by Western blot (p19 and\/or p24 bands) were found negative by polymerase chain reaction using LTR,\n                    <jats:italic toggle=\"yes\">pol<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">tax<\/jats:italic>\n                    HTLV-I specific primers. A long-term T cell line, designated Mel.J, exhibiting T cell activation markers (CD4\n                    <jats:sup>+<\/jats:sup>\n                    , CD25\n                    <jats:sup>+<\/jats:sup>\n                    , HLA-DR\n                    <jats:sup>+<\/jats:sup>\n                    ), and producing HTLV-I antigens and viral particles, was established from one of the HTLV-I,-seropositive patients. The sequence of a 522-bp fragment corresponding to the carboxy terminus of gp46 and the majority of gp21 were determined for five HTLV-I-seropositive individuals, including the TSP\/HAM patient. Alignment and phylogenetic comparison of these five nucleotide sequences with all the 53 other available HTLV-I\n                    <jats:italic toggle=\"yes\">env<\/jats:italic>\n                    sequences demonstrated that the virus from La R\u00e9union Island belongs to the group of the HTLV-I cosmopolitan subtype and is not related to the Melanesian HTLV-I variants.\n                  <\/jats:p>","DOI":"10.1089\/aid.1994.10.745","type":"journal-article","created":{"date-parts":[[2009,3,16]],"date-time":"2009-03-16T14:21:27Z","timestamp":1237213287000},"page":"745-752","source":"Crossref","is-referenced-by-count":23,"title":["Seroepidemiology, Viral Isolation, and Molecular Characterization of Human T Cell Leukemia\/Lymphoma Virus Type I from La R\u00e9union Island, Indian Ocean"],"prefix":"10.1177","volume":"10","author":[{"given":"Renaud","family":"Mahieux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Gessain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Truffert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Vitrac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Hubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dandelot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Montchamp-Moreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Cnudde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredj","family":"Tekaia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"de Th\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1994,6,1]]},"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.1994.10.745","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.1994.10.745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:21:41Z","timestamp":1774621301000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/aid.1994.10.745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1994,6]]}},"alternative-id":["10.1089\/aid.1994.10.745"],"URL":"https:\/\/doi.org\/10.1089\/aid.1994.10.745","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,6]]}}}