{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:13:54Z","timestamp":1777378434331,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>The distribution of antiretroviral (ARV) therapy resistance mutations among HIV-1 strains was evaluated in 39 postpartum women, one pregnant woman, and 12 HIV-positive babies (seven newborns and five children) living in rural west Cameroon. Thirty-five women and all newborns received a single dose of nevirapine (NVP) to prevent mother-to-child transmission of HIV-1; two women were ARV treated and three were ARV naive. Of the 52 viral strains examined, three were subtype B, 45 were classified into eight HIV-1 non-B subtypes, and four remained unclassifiable. Sequence analysis for genotypic drug resistance in the reverse transcriptase (RT) gene showed the presence of mutations associated with nonnucleoside RT inhibitor resistance in 20% of the samples from NVP-treated women and in 57% of those from treated newborns. Mutations associated with nucleoside RT inhibitors (M184V in one case and V118I in four cases) were found in five samples, despite being derived from ARV-naive patients. As expected, a greater frequency of mutations was found in the protease gene region. Of the sequences analyzed, 79% harbored five to seven specific mutations. The secondary mutations showed the typical protease inhibitor resistance-associated pattern for non-subtype B viruses, M36I being the predominant mutation (92.5% in women, 100% in babies). Other mutations frequently detected were K20I, L63P, H69K, and I13V. These findings confirm that resistance mutations can be detected in ARV-naive patients infected with non-B subtypes and emphasize an urgent need for studies assessing the impact of these mutations on the efficacy of subsequent ARV therapy and on the appearance of drug-resistant strains.<\/jats:p>","DOI":"10.1089\/aid.2007.0213","type":"journal-article","created":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T15:57:00Z","timestamp":1211990220000},"page":"781-785","source":"Crossref","is-referenced-by-count":12,"title":["Study of the Genotypic Resistant Pattern in HIV-Infected Women and Children from Rural West Cameroon"],"prefix":"10.1177","volume":"24","author":[{"given":"Ombretta","family":"Turriziani","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine, Virology Section, \u201cSapienza\u201d University of Rome, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases, \u201cSapienza\u201d University of Rome, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Lichtner","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases, \u201cSapienza\u201d University of Rome, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Stano","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Virology Section, \u201cSapienza\u201d University of Rome, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle","family":"Tsague","sequence":"additional","affiliation":[{"name":"Dschang Hospital District, Cameroon."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Maida","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Virology Section, \u201cSapienza\u201d University of Rome, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Vullo","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases, \u201cSapienza\u201d University of Rome, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Virology Section, \u201cSapienza\u201d University of Rome, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,6,1]]},"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2007.0213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2007.0213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:11:03Z","timestamp":1777367463000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/aid.2007.0213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1089\/aid.2007.0213"],"URL":"https:\/\/doi.org\/10.1089\/aid.2007.0213","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}