{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:13:50Z","timestamp":1777378430183,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>Resistance-associated mutations (RAMs) in plasma samples from HIV-1-infected women who received antiretroviral (ARV) prophylaxis during pregnancy was assessed and correlated with the detection of RAMs in peripheral blood mononuclear cells (PMBCs). The study population was composed of HIV-1-infected women enrolled in a prospective cohort study in Latin America and the Caribbean (NISDI Perinatal Study) as of March 1, 2005, who were diagnosed with HIV-1 infection during the current pregnancy, who received ARVs during pregnancy for prevention of mother-to-child transmission of HIV-1, and who were followed through at least the 6\u201312 week postpartum visit. Plasma samples collected at enrollment during pregnancy and at 6\u201312 weeks postpartum were assayed for RAMs. Plasma results were compared to previously described PBMC results from the same study population. Of 819 enrolled subjects, 197 met the eligibility criteria. Nucleic acid amplification was accomplished in 123 plasma samples at enrollment or 6\u201312 weeks postpartum, and RAMs were detected in 22 (17.9%; 95%CI: 11.7\u201325.9%). Previous analyses had demonstrated detection of RAMs in PBMCs in 19 (16.1%). There was high concordance between RAMs detected in plasma and PBMC samples, with only eight discordant pairs. The prevalence of RAMs among these pregnant, HIV-1-infected women is high (&gt;15%). Rates of detection of RAMs in plasma and PBMC samples were similar.<\/jats:p>","DOI":"10.1089\/aid.2007.0246","type":"journal-article","created":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T15:57:00Z","timestamp":1211990220000},"page":"797-804","source":"Crossref","is-referenced-by-count":11,"title":["Antiretroviral Resistance among HIV Type 1-Infected Women First Exposed to Antiretrovirals during Pregnancy: Plasma versus PBMCs"],"prefix":"10.1177","volume":"24","author":[{"given":"Luis E.","family":"Soto-Ramirez","sequence":"first","affiliation":[{"name":"Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Rodriguez-Diaz","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana S.","family":"Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Hospital General de Agudos Jose Maria Ramos Mejia","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo H.","family":"Losso","sequence":"additional","affiliation":[{"name":"Hospital General de Agudos Jose Maria Ramos Mejia","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horacio","family":"Salom\u00f3n","sequence":"additional","affiliation":[{"name":"University of Buenos Aires","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"G\u00f3mez-Carrillo","sequence":"additional","affiliation":[{"name":"University of Buenos Aires","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Pampuro","sequence":"additional","affiliation":[{"name":"University of Buenos Aires","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Robert","family":"Harris","sequence":"additional","affiliation":[{"name":"Westat"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldo","family":"Duarte","sequence":"additional","affiliation":[{"name":"University of Sao Paulo at Ribeirao Preto","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo S.","family":"De Souza","sequence":"additional","affiliation":[{"name":"University de Caxias do Sul","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer S.","family":"Read","sequence":"additional","affiliation":[{"name":"CRMC, NICHD, NIH, DHHS"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,6,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411033311801"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)80008-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033500"},{"key":"e_1_3_2_5_2","unstructured":"Centers for Disease Control and Prevention. U.S. Public Health Service Task Force Recommendations for use of antiretroviral drugs in pregnant HIV-infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States. MMWR Morb Mortal Week Rep 2005; 47:1\u201330(Most recent revision of the guidelineswww.aidsinfo.nih.gov.)"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/427287"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200626110-00001"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200309010-00001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328011770b"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000265211.76196.ac"},{"key":"e_1_3_2_11_2","first-page":"125","article-title":"Update of the drug resistance mutation in HIV-1: Fall 2006","volume":"14","author":"Johnson VA","year":"2006","unstructured":"Johnson VA, , Brun-V\u00e9zinet F, , Clotet B et al. Update of the drug resistance mutation in HIV-1: Fall 2006. Top HIV Med, 2006; 14:125\u2013130.","journal-title":"Top HIV Med"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/38.1-2.141"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/001316446002000104"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.1.406-413.2005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000176226.63732.71"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.16.2083"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200307040-00022"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200501030-00007"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2022"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/08892220050075273"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2006.12.018"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200308150-00006"}],"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2007.0246","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/aid.2007.0246","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2007.0246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:11:03Z","timestamp":1777367463000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/aid.2007.0246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1089\/aid.2007.0246"],"URL":"https:\/\/doi.org\/10.1089\/aid.2007.0246","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}