{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:28:25Z","timestamp":1791080905676,"version":"4.1.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>\n                    Clonal disorders of large granular lymphocytes (LGL) result in leukemia due to the expansion of a discrete subset of either CD3\n                    <jats:sup>+<\/jats:sup>\n                    T cells or natural killer (NK) cells. It has been hypothesized that a viral antigen acts as the initial stimulus causing the expansion of these cells. The possible involvement of human T cell lymphotropic virus types 1 and 2 (HTLV-1 and HTLV-2) in this disease has been studied but no conclusive evidence has linked either virus with LGL leukemia. In this study, we examined whether HTLV-3 or HTLV-4, two newly identified HTLV groups discovered in Central Africa in primate hunters, is involved in LGL leukemia. We developed two specific real-time PCR quantitative assays that are highly sensitive, capable of detecting 10 copies of HTLV-3 or HTLV-4\n                    <jats:italic toggle=\"yes\">pol<\/jats:italic>\n                    sequences in a background of 1\n                    <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>\n                    g of DNA from human peripheral blood lymphocytes (PBL). We tested PBL DNA samples from 40 LGL leukemia patients in the United States and found that all samples were negative for HTLV-3 or HTLV-4 infection. These results suggest that HTLV-3 and HTLV-4 are not the causative agent of LGL leukemia.\n                  <\/jats:p>","DOI":"10.1089\/aid.2008.0128","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T15:29:39Z","timestamp":1229959779000},"page":"1503-1505","source":"Crossref","is-referenced-by-count":32,"title":["<i>Short Communication:<\/i>\n                    Absence of Evidence of HTLV-3 and HTLV-4 in Patients with Large Granular Lymphocyte (LGL) Leukemia"],"prefix":"10.1177","volume":"24","author":[{"given":"Yen T.","family":"Duong","sequence":"first","affiliation":[{"name":"Laboratory Branch, Division of HIV\/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Jia","sequence":"additional","affiliation":[{"name":"Laboratory Branch, Division of HIV\/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Lust","sequence":"additional","affiliation":[{"name":"Mayo Clinic of Medicine, Rochester, Minnesota 55905."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert D.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Laboratory Branch, Division of HIV\/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Tiffany","sequence":"additional","affiliation":[{"name":"Laboratory Branch, Division of HIV\/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Heneine","sequence":"additional","affiliation":[{"name":"Laboratory Branch, Division of HIV\/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Switzer","sequence":"additional","affiliation":[{"name":"Laboratory Branch, Division of HIV\/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,12,1]]},"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2008.0128","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2008.0128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:10:45Z","timestamp":1777367445000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/aid.2008.0128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["10.1089\/aid.2008.0128"],"URL":"https:\/\/doi.org\/10.1089\/aid.2008.0128","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}