{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:12:15Z","timestamp":1777378335600,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>\n                    Class 1 and class 2 fusion peptides bind to the trimeric N-terminal heptad repeat (NHR) and C-terminal heptad repeat (CHR) regions of HIV-1 envelope glycoprotein gp41, respectively, and block its intramolecular folding required for Env-mediated viral and host cell membrane fusion and subsequent viral entry. Using a combination of T-20 (class 1) and (CCIZN17)\n                    <jats:sub>3<\/jats:sub>\n                    (class 2), we provide evidence that these classes of fusion peptides work synergistically in an\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    infectivity assay in inhibiting the entry of primary HIV-1 isolate 89.6 with combination indexes reaching 0.37 and 0.32 at IC\n                    <jats:sub>50<\/jats:sub>\n                    and IC\n                    <jats:sub>90<\/jats:sub>\n                    , respectively. We further demonstrate a similar degree of neutralization synergy between a monoclonal antibody (MAb), D5, targeting the hydrophobic pocket region of the NHR, and 2F5, a well-characterized MAb that targets the C-terminal end of CHR and the membrane-proximal external region (MPER), providing a rational basis for developing combination vaccines targeting these two highly conserved regions of gp41.\n                  <\/jats:p>","DOI":"10.1089\/aid.2008.0129","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T15:29:39Z","timestamp":1229959779000},"page":"1537-1544","source":"Crossref","is-referenced-by-count":12,"title":["<i>Short Communication: In Vitro<\/i>\n                    Synergy between Peptides or Neutralizing Antibodies Targeting the N- and C-Terminal Heptad Repeats of HIV Type 1 gp41"],"prefix":"10.1177","volume":"24","author":[{"given":"Renee","family":"Hrin","sequence":"first","affiliation":[{"name":"Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania 19486."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna L.","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Department of Biologics Research, Merck Research Laboratories, West Point, Pennsylvania 19486."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fubao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biologics Research, Merck Research Laboratories, West Point, Pennsylvania 19486."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon H.","family":"Condra","sequence":"additional","affiliation":[{"name":"Department of Biologics Research, Merck Research Laboratories, West Point, Pennsylvania 19486."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"An","sequence":"additional","affiliation":[{"name":"Department of Biologics Research, Merck Research Laboratories, West Point, Pennsylvania 19486."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Strohl","sequence":"additional","affiliation":[{"name":"Department of Biologics Research, Merck Research Laboratories, West Point, Pennsylvania 19486."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche di Biologia Molecolare P. Angeletti, I-00040 Pomezia (Rome), Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonello","family":"Pessi","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche di Biologia Molecolare P. Angeletti, I-00040 Pomezia (Rome), Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph G.","family":"Joyce","sequence":"additional","affiliation":[{"name":"Department of Vaccines Research, Merck Research Laboratories, West Point, Pennsylvania 19486."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania 19486."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,12,1]]},"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2008.0129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2008.0129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:10:45Z","timestamp":1777367445000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/aid.2008.0129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["10.1089\/aid.2008.0129"],"URL":"https:\/\/doi.org\/10.1089\/aid.2008.0129","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}