{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:15:48Z","timestamp":1777378548890,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>\n                    Metabolic disturbances such as dyslipidemia, lipodystrophy syndrome, visceral obesity, hyperlactatemia, diabetes mellitus, and hepatic steatosis have been recognized as serious complications in long-term antiretroviral-treated HIV-infected patients. The oxidative capacity of liver mitochondria plays a central role in their pathogenesis and can be analyzed using the [\n                    <jats:sup>13<\/jats:sup>\n                    C]methionine breath test. We analyzed hepatic mitochondrial function using the [\n                    <jats:sup>13<\/jats:sup>\n                    C]methionine breath test in antiretrovirally treated and untreated HIV-infected patients as well as HIV-negative controls. Patients with hepatic steatosis, hypertriglyceridemia, lipohypertrophy, and older age showed reduced methionine metabolism. Hepatic mitochondrial function is impaired in antiretroviral-treated HIV-infected patients with disturbances of lipid metabolism.\n                  <\/jats:p>","DOI":"10.1089\/aid.2009.0013","type":"journal-article","created":{"date-parts":[[2009,12,9]],"date-time":"2009-12-09T19:35:41Z","timestamp":1260387341000},"page":"1243-1248","source":"Crossref","is-referenced-by-count":2,"title":["[\n                    <sup>13<\/sup>\n                    C]Methionine Breath Test as a Marker for Hepatic Mitochondrial Function in HIV-Infected Patients"],"prefix":"10.1177","volume":"25","author":[{"given":"T.","family":"Sternfeld","sequence":"first","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Klinikum Deggendorf","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Schmid","sequence":"additional","affiliation":[{"name":"University Hospital of Munich","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Schlamp","sequence":"additional","affiliation":[{"name":"University Hospital of Munich","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Demmelmair","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians University Munich","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Koletzko","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians University Munich","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.R.","family":"Bogner","sequence":"additional","affiliation":[{"name":"University Hospital of Munich","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,12,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2007.00508.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2004.00237.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/em.20223"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(00)90004-3"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(98)00067-X"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000179465.48571.d5"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh497"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200404010-00015"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750023633"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2000.6012"},{"key":"e_1_3_3_12_2","first-page":"CR6","article-title":"Impaired hepatic mitochondrial oxidation using the 13C-methionine breath test in patients with macrovesicular steatosis and patients with cirrhosis","volume":"9","author":"Spahr L","year":"2003","unstructured":"Spahr L, , Negro F, , Leandro G et al. Impaired hepatic mitochondrial oxidation using the 13C-methionine breath test in patients with macrovesicular steatosis and patients with cirrhosis. Med Sci Monit, 2003; 9:CR6\u2013CR11.","journal-title":"Med Sci Monit"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/135965350501002S07"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012791832730"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01824.x"},{"key":"e_1_3_3_16_2","first-page":"23","article-title":"13C-breath tests in the study of mitochondrial liver function","volume":"8","author":"Candelli M","year":"2004","unstructured":"Candelli M, , Cazzato IA, , Zocco MA et al. 13C-breath tests in the study of mitochondrial liver function. Eur Rev Med Pharmacol Sci, 2004; 8:23\u201331.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07725.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.meg.0000059158.46867.a6"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01374.x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.106.2763.589"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(81)90489-3"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1027343915452"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-12929"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000167478.28051.3a"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000195606.48133.ed"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509776102"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200304001-00017"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867053363081"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.03.005"}],"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2009.0013","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/aid.2009.0013","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2009.0013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:11:30Z","timestamp":1777367490000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/aid.2009.0013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1089\/aid.2009.0013"],"URL":"https:\/\/doi.org\/10.1089\/aid.2009.0013","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}