{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:40:07Z","timestamp":1792251607535,"version":"4.4.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>\n                    We investigated the effect of antioxidant supplementation on mitochondrial function, fat distribution, and lipid and glucose metabolism in HIV-1-infected patients with antiretroviral therapy (ART)-related lipoatrophy. 61 ART-treated HIV-1-infected patients with lipoatrophy were randomized to receive either n-acetyl-L-carnitine (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200921), lipoic acid\u2009+\u2009n-acetylcisteine (LA\/NAC) (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200920), or no supplementation (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200920) for 48 weeks. At baseline and at the end of treatment, mitochondrial function was studied by\n                    <jats:sup>13<\/jats:sup>\n                    C-methionine breath test and by mitochondrial (mt)-DNA quantification on circulating T-cells and subcutaneous adipose tissue. Body composition was assessed by dual-energy X-ray absorpiometry (DEXA).\n                    <jats:sup>13<\/jats:sup>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    -exhalation increased between baseline and week 48 in both supplementation arms as evidenced by a higher delta over baseline excretion at 45\u2009min (from mean\u2009\u00b1\u2009SEM of 7.8\u2009\u00b1\u20091.08 to 9.9\u2009\u00b1\u20090.6,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.04 in the n-acetyl-carnitine arm, and from 7.4\u2009\u00b1\u20090.8 to 11.5\u2009\u00b1\u20091.6,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.01 in LA\/NAC arm). Cumulative\n                    <jats:sup>13<\/jats:sup>\n                    CO2 excretion increased from median (interquartile range; IQR) of 3.25 (2.55\u20134.2) to 4.51 (4.12\u20135.2) in the carnitine arm; from 3.79 (2.67\u20134.37) to 4.83 (4.25\u20135.56) in the LA\/NAC arm;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.004, 0.02, respectively. mtDNA content increased in CD4+ T-cells from patients who received n-acetyl-carnitine (+30 copies\/cell;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.03), without significant difference by the overall comparison of the study groups. Fat body mass and lipid profile did not change significantly in any of the arms. Our study showed that antioxidant supplementation may have a protective role on mitochondrial function, with limited effects on the reversal of clinical lipodystrophic abnormalities in HIV-1-infected patients.\n                  <\/jats:p>","DOI":"10.1089\/aid.2010.0024","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T16:56:05Z","timestamp":1288112165000},"page":"1207-1214","source":"Crossref","is-referenced-by-count":16,"title":["Effect of Antioxidants on Mitochondrial Function in HIV-1\u2013Related Lipoatrophy: A Pilot Study"],"prefix":"10.1177","volume":"26","author":[{"given":"Laura","family":"Milazzo","sequence":"first","affiliation":[{"name":"Universit\u00e0 degli Studi di Milano","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Menzaghi","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Milano","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Caramma","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Milano","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Nasi","sequence":"additional","affiliation":[{"name":"Universit\u00e0 di Modena e Reggio Emilia","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornella","family":"Sangaletti","sequence":"additional","affiliation":[{"name":"L. 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