{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:12:28Z","timestamp":1777378348237,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>Recent reports have suggested an increased risk of acute hepatitis C (AHC) infection in homosexual HIV-infected men and that early treatment with interferon-alfa, alone or associated with ribavirin, significantly reduces the risk of chronic evolution. A retrospective analysis of 38 HIV-infected patients who were consecutively diagnosed as developing AHC, defined by both seroconversion of anti-hepatitis C virus (HCV) antibodies and detection of serum HCV-RNA in those with previous negative results.<\/jats:p>\n                  <jats:p>Thirty-six patients were men with history of unprotected sexual intercourse with men and two were women with sexual and nosocomial risk factors. AHC infection was asymptomatic in 26 patients; asthenia and jaundice were the most frequent symptoms. HCV genotype 1 was present in 19 patients and genotype 4 in 14 patients. Thirty-five patients received early antiviral treatment with pegylated interferon-alfa associated with ribavirin; 15 of the 32 patients who completed the follow-up (47%) achieved a sustained virological response, as defined by undetectable HCV-RNA 6 months after the end of therapy. There is a risk of sexual transmission of HCV in HIV-infected men who have sex with men. In our experience, early treatment of AHC with pegylated interferon-alfa plus ribavirin in HIV patients achieves poor results.<\/jats:p>","DOI":"10.1089\/aid.2011.0289","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T07:39:10Z","timestamp":1332229150000},"page":"1294-1300","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Low Rate of Sustained Virological Response in an Outbreak of Acute Hepatitis C in HIV-Infected Patients"],"prefix":"10.1177","volume":"28","author":[{"given":"Montserrat","family":"Laguno","sequence":"first","affiliation":[{"name":"University of Barcelona","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Mart\u00ednez-Rebollar","sequence":"additional","affiliation":[{"name":"University of Barcelona","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u00f1aki","family":"Perez","sequence":"additional","affiliation":[{"name":"University of Barcelona","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Costa","sequence":"additional","affiliation":[{"name":"University of Barcelona","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Larrousse","sequence":"additional","affiliation":[{"name":"University of Barcelona","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Calvo","sequence":"additional","affiliation":[{"name":"University of Barcelona","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montse","family":"Lonc\u00e1","sequence":"additional","affiliation":[{"name":"University of Barcelona","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"University of Barcelona","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Gonz\u00e1lez-Cord\u00f3n","sequence":"additional","affiliation":[{"name":"University of Barcelona","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Lu\u00eds","family":"Blanco","sequence":"additional","affiliation":[{"name":"University of Barcelona","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"University of Barcelona","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep Maria","family":"Gatell","sequence":"additional","affiliation":[{"name":"University of Barcelona","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Mallolas","sequence":"additional","affiliation":[{"name":"University of Barcelona","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833c11a5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000171412.61360.f8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3281053a0c"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000200541.40633.56"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000191281.77954.27"},{"key":"e_1_3_3_7_2","volume-title":"14th International Symposium on Hepatitis C Virus and Related Viruses","author":"Bateman K","year":"2007","unstructured":"Bateman K, , Factor S, , Gutierrez J. 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