{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:12:47Z","timestamp":1777378367862,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>\n                    The distribution of HIV-1 subtypes and genetic characterization of CRF01_AE in Guangxi, southern China were identified. The distribution of HIV-1 genotypes based on\n                    <jats:italic toggle=\"yes\">gag<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">pol<\/jats:italic>\n                    , and partial\n                    <jats:italic toggle=\"yes\">env<\/jats:italic>\n                    sequences (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =349) was as follows: CRF01_AE (66.5%), CRF08_BC (19.2%), CRF07_BC (7.2%), URF (4.6%), subtype B (1.7%), and subtype B\u2032 (0.9%). CRF01_AE predominated in all geographic regions and risk populations and there were multiple introductions of CRF01_AE strains in Guangxi. We found a peculiar CRF01_AE monophyletic lineage distinct from other CRF01_AE viruses, and we designated it \u201cCRF01_AE-v\u201d for convenience. CRF01_AE-v circulating in both heterosexuals and injecting drug users (IDUs) had accounted for 39.7% of CRF01_AE. It showed a selective advantage in the Guangxi population and formed its own characteristic compared with all the CRF01_AE references. Our results suggested that CRF01_AE-v was a new variant of CRF01_AE and it might lead to a new epidemic in Guangxi.\n                  <\/jats:p>","DOI":"10.1089\/aid.2011.0364","type":"journal-article","created":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T22:10:49Z","timestamp":1327097449000},"page":"1352-1356","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Emergence of a New HIV Type 1 CRF01_AE Variant in Guangxi, Southern China"],"prefix":"10.1177","volume":"28","author":[{"given":"Haiyan","family":"Zeng","sequence":"first","affiliation":[{"name":"Chinese Academy of Sciences","place":["The People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwu","family":"Sun","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences","place":["The People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujia","family":"Liang","sequence":"additional","affiliation":[{"name":"Guangxi Province Center for Disease Prevention and Control","place":["The People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingnuo","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences","place":["The People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences","place":["The People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Province Center for Disease Prevention and Control","place":["The People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binlian","family":"Sun","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences","place":["The People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyun","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Institute of Microbiology and Epidemiology","place":["The People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongge","family":"Yang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences","place":["The People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030443"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2009.0002"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181c7d5bf"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328329217d"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2006.0196"},{"issue":"3","key":"e_1_3_3_7_2","first-page":"356","article-title":"Molecular epidemiology of HIV-1 subtypes in southern China","volume":"38","author":"Laeyendecker O","year":"2005","unstructured":"Laeyendecker O, , Zhang GW, , Quinn TC et al. 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