{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:12:46Z","timestamp":1777378366329,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>\n                    Single nucleotide polymorphisms (SNP) nearby the\n                    <jats:italic toggle=\"yes\">IL28B<\/jats:italic>\n                    gene have been associated with spontaneous hepatitis C virus (HCV) clearance and response to interferon-based therapies in both monoinfected and HIV-coinfected patients. However, its impact on spontaneous clearance of HBV (the pathogenesis of which is also related to interferon) is less known. A case-control study was performed. Cases were 49 HIV\n                    <jats:sup>+<\/jats:sup>\n                    patients with chronic hepatitis B (HBsAg\n                    <jats:sup>+<\/jats:sup>\n                    for more than 6 months) who had been genotyped for the rs12979860 SNP (protective CC genotype). One control for each case was chosen among HIV patients with anti-HBs and anti-HBc. Controls were matched for gender and coinfection with HCV. Most patients were male (90%) and the median (IQR) age was 42.6 (39\u201346.7) years. Eighteen (36.7%) were also coinfected by HCV. Among HBsAg\n                    <jats:sup>+<\/jats:sup>\n                    patients, 19 (41.3%) were HBeAg\n                    <jats:sup>+<\/jats:sup>\n                    and 13 (26.5%) were also infected with hepatitis delta (HDV). No differences were found in the distribution of the CC genotype between patients with chronic hepatitis B and those who spontaneously cured hepatitis B: 59.2% vs. 44.9%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.3. Thus, the interleukin-28B (\n                    <jats:italic toggle=\"yes\">IL-28B<\/jats:italic>\n                    ) genotype does not seem to have a role in the development of chronic hepatitis B among HIV-infected patients.\n                  <\/jats:p>","DOI":"10.1089\/aid.2011.0365","type":"journal-article","created":{"date-parts":[[2012,2,12]],"date-time":"2012-02-12T19:01:12Z","timestamp":1329073272000},"page":"1262-1264","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Short Communication: Does Interleukin-28B Single Nucleotide Polymorphisms Influence the Natural History of Hepatitis B?"],"prefix":"10.1177","volume":"28","author":[{"given":"Luz","family":"Mart\u00edn-Carbonero","sequence":"first","affiliation":[{"name":"Hospital Carlos III","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma I.","family":"Rall\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Carlos III","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Benito","sequence":"additional","affiliation":[{"name":"Hospital Carlos III","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Poveda","sequence":"additional","affiliation":[{"name":"Hospital Carlos III","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Gonz\u00e1lez-Lahoz","sequence":"additional","affiliation":[{"name":"Hospital Carlos III","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Soriano","sequence":"additional","affiliation":[{"name":"Hospital Carlos III","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08463"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08309"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283391d6d"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/657146"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2011.01835.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f8b46f"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040516"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni875"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.6.3851-3854.2005"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05384.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20944"},{"key":"e_1_3_3_13_2","first-page":"173","article-title":"Immunizations in HIV-infected adults","volume":"9","author":"Rivas P","year":"2007","unstructured":"Rivas P, , Herrero MD, , Puente S et al. Immunizations in HIV-infected adults. AIDS Rev, 2007; 9:173\u2013187.","journal-title":"AIDS Rev"}],"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2011.0365","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/aid.2011.0365","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2011.0365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:10:50Z","timestamp":1777367450000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/aid.2011.0365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1089\/aid.2011.0365"],"URL":"https:\/\/doi.org\/10.1089\/aid.2011.0365","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}