{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:09:04Z","timestamp":1779106144393,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>\n                    The present study aimed to evaluate the role of genetic polymorphisms in the emergence of lipoatrophy or lipodystrophy in HIV-infected patients with antiretroviral therapy (ART) in Thailand. Position 455 upstream of the\n                    <jats:italic toggle=\"yes\">Apolipoprotein C3<\/jats:italic>\n                    gene (\n                    <jats:italic toggle=\"yes\">ApoC3<\/jats:italic>\n                    T\u2013455C, rs2854116), codon 64 of the\n                    <jats:italic toggle=\"yes\">Beta3 adrenergic receptor<\/jats:italic>\n                    gene (\n                    <jats:italic toggle=\"yes\">AR\u03b23<\/jats:italic>\n                    Tcod64C, rs4994), and position 670 upstream of the\n                    <jats:italic toggle=\"yes\">Fas<\/jats:italic>\n                    gene (\n                    <jats:italic toggle=\"yes\">Fas<\/jats:italic>\n                    A\u2013670G, rs1800682) were genotyped in 829 HIV-infected Thai patients who had started ART. Crude and adjusted incidence rate ratios (IRR) were calculated using Poisson regression. The serum levels of cholesterol, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were also analyzed. Multivariate analysis revealed an association between the\n                    <jats:italic toggle=\"yes\">Fas<\/jats:italic>\n                    \u2212670AA genotype, but not the\n                    <jats:italic toggle=\"yes\">ApoC3<\/jats:italic>\n                    \u2212455 or\n                    <jats:italic toggle=\"yes\">AR\u03b23<\/jats:italic>\n                    cod64 genotypes, with the incidence of lipoatrophy after adjusting for gender and stavudine (d4T)-containing regimens (IRR=1.72, 95% CI=1.20\u20132.45,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.003). However,\n                    <jats:italic toggle=\"yes\">ApoC3<\/jats:italic>\n                    \u2212455C homozygous patients showed elevated serum levels of triglycerides, while this genotype did not affect serum total cholesterol, HDL, or LDL levels in patients with lipoatrophy or lipodystrophy. In contrast, the\n                    <jats:italic toggle=\"yes\">AR\u03b23<\/jats:italic>\n                    cod64 genotype did not show any significant association with the serum levels of cholesterol, triglycerides, HDL, or LDL. In conclusion,\n                    <jats:italic toggle=\"yes\">Fas<\/jats:italic>\n                    \u2212670AA affected the incidence of lipoatrophy in HIV-1-infected Thai patients, while the\n                    <jats:italic toggle=\"yes\">ApoC3<\/jats:italic>\n                    \u2212455C allele affected the serum levels of triglycerides. These results confirmed the role of genetics in the development of ART-related metabolic disorders.\n                  <\/jats:p>","DOI":"10.1089\/aid.2012.0114","type":"journal-article","created":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T22:49:37Z","timestamp":1341874177000},"page":"142-150","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Polymorphisms in\n                    <i>Fas<\/i>\n                    Gene Is Associated with HIV-Related Lipoatrophy in Thai Patients"],"prefix":"10.1177","volume":"29","author":[{"given":"Sirirat","family":"Likanonsakul","sequence":"first","affiliation":[{"name":"Bamrasnaradura Infectious Diseases Institute","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tippawan","family":"Rattanatham","sequence":"additional","affiliation":[{"name":"Bamrasnaradura Infectious Diseases Institute","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siriluk","family":"Feangvad","sequence":"additional","affiliation":[{"name":"Bamrasnaradura Infectious Diseases Institute","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumonmal","family":"Uttayamakul","sequence":"additional","affiliation":[{"name":"Bamrasnaradura Infectious Diseases Institute","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wisit","family":"Prasithsirikul","sequence":"additional","affiliation":[{"name":"Bamrasnaradura Infectious Diseases Institute","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somkid","family":"Srisopha","sequence":"additional","affiliation":[{"name":"Bamrasnaradura Infectious Diseases Institute","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravee","family":"Nitiyanontakij","sequence":"additional","affiliation":[{"name":"Bamrasnaradura Infectious Diseases Institute","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pimrapat","family":"Tengtrakulcharoen","sequence":"additional","affiliation":[{"name":"Mahidol University","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Tarkowski","sequence":"additional","affiliation":[{"name":"University of Milan","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agostino","family":"Riva","sequence":"additional","affiliation":[{"name":"University of Milan","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi E.","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Osaka University","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Shioda","sequence":"additional","affiliation":[{"name":"Osaka University","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199907090-00001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.13.2050"},{"key":"e_1_3_3_4_2","first-page":"225","article-title":"Diabetes, insulin resistance and dyslipidaemia in lipodystrophic HIV-infected patients on highly active antiretroviral therapy (HAART)","volume":"25","author":"Vigouroux C","year":"1999","unstructured":"Vigouroux C, , Gharakhanian S, , Salhi Y et al. 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