{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:09:21Z","timestamp":1779106161418,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>\n                    We assessed the relationship between atazanavir (ATV)-based antiretroviral treatment (ART) and plasma hepatitis C virus (HCV) viral load in a population of HIV\/HCV-coinfected patients. HIV\/HCV-coinfected patients who received ART based on a protease inhibitor (PI) or nonnucleoside reverse transcriptase inhibitor (NNRTI) were included. Patients were stratified by ART drug [ATV\/rtv, lopinavir (LPV\/rtv), efavirenz (EFV), nevirapine (NVP), and other PIs], HCV genotype (1\/4 and 2\/3), and IL28B genotype (CC and non-CC). The Kruskal\u2013Wallis test and chi-squared test were used to compare continuous and categorical variables, respectively. Multivariate analysis consisted of a stepwise linear regression analysis. Six hundred and forty-nine HIV\/HCV-coinfected patients were included. HCV genotype 1\/4 patients who received ATV had higher HCV RNA levels [6.57 (5.9\u20136.8) log IU\/ml] than those who received LPV [6.1 (5.5\u20136.5) log IU\/ml], EFV [6.1 (5.6\u20136.4) log IU\/ml], NVP [5.8 (5.5\u20135.9) log IU\/ml], or other PIs [6.1 (5.7\u20136.4) log IU\/ml] (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.014). This association held for the IL28B genotype (CC versus non-CC). The association was not found in patients carrying HCV genotypes 2\/3. The linear regression model identified the IL28B genotype and ATV use as independent factors associated with HCV RNA levels. ATV-based therapy may be associated with a higher HCV RNA viral load in HIV\/HCV-coinfected patients.\n                  <\/jats:p>","DOI":"10.1089\/aid.2012.0126","type":"journal-article","created":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T23:39:50Z","timestamp":1347406790000},"page":"223-225","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Short Communication: Atazanavir-Based Therapy Is Associated with Higher Hepatitis C Viral Load in HIV Type 1-Infected Subjects with Untreated Hepatitis C"],"prefix":"10.1177","volume":"29","author":[{"given":"Antonio","family":"Rivero-Juarez","sequence":"first","affiliation":[{"name":"Hospital Universitario Reina Sofia","place":["Spain"]},{"name":"Maimonides Institute for Biomedical Research (IMIBIC)","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A.","family":"Mira","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Valme","place":["Spain"]},{"name":"Hospital Universitario de Valme","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Santos-Gil","sequence":"additional","affiliation":[{"name":"Hospital Universitario de la Princesa","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis F.","family":"Lopez-Cortes","sequence":"additional","affiliation":[{"name":"Hospitales Universitarios Virgen del Rocio","place":["Spain"]},{"name":"Instituto de Biomedicina de Sevilla (IBIS)","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A","family":"Gir\u00f3n-Gonzalez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta del Mar","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Marquez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen de la Victoria","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Merino","sequence":"additional","affiliation":[{"name":"Hospital Juan Ram\u00f3n Jim\u00e9nez","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Tellez","sequence":"additional","affiliation":[{"name":"Hospital de La L\u00ednea de la Concepci\u00f3n","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Caruz","sequence":"additional","affiliation":[{"name":"Universidad de Ja\u00e9n","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A","family":"Pineda","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Biomedical Research (IMIBIC)","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Rivero, on behalf of the Grupo Andaluz para el Estudio de la","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sofia","place":["Spain"]},{"name":"Maimonides Institute for Biomedical Research (IMIBIC)","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00522.2005"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23339"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23921"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412687200"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950151108"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr357"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328216f2c7"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010494"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1012912"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.4172\/2155-6113.1000110"}],"container-title":["AIDS 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