{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:26:46Z","timestamp":1787819206706,"version":"build-2784847793"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>\n                    HIV infection is considered a risk factor for the development of pulmonary arterial hypertension (PAH) and the estimated prevalence of PAH in developed countries is 0.5%. The aim of this study was to determine the prevalence of PAH in a cohort of HIV-infected patients and the related factors. We undertook an observational study of a consecutive cohort of asymptomatic HIV-infected patients. Data were recorded about factors of cardiovascular interest and factors related to HIV infection. All the patients underwent a transthoracic echocardiogram (Vivid S6, GE Healthcare). PAH was considered to be a pulmonary arterial systolic pressure (PASP) &gt;40\u2009mm Hg. The study included 194 patients (85.2% men) with a mean age of 47.0 years, 94% of whom were on antiretroviral therapy (ART). The mean CD4 lymphocyte count was 495\/mm\n                    <jats:sup>3<\/jats:sup>\n                    . The mean duration of HIV infection was 131.5 months, and 28.4% had experienced an AIDS event. PAH was present in five patients (2.6%) and 14 were in the gray zone (PASP of 36\u201340\u2009mm Hg). These five patients were men, the route of transmission was homosexual, and they were all on ART. They were also older than the patients without PAH (57.7 vs. 46.4 years,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.02) and had been on ART for longer (180.0 vs. 92.5 months;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.01). No association was found with any of the other parameters. The prevalence of PAH in this cohort of patients was greater than in other published series. The only associations found were with older age and longer ART time.\n                  <\/jats:p>","DOI":"10.1089\/aid.2012.0166","type":"journal-article","created":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:12:44Z","timestamp":1343779964000},"page":"231-234","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["High Prevalence of Pulmonary Arterial Hypertension in a Cohort of Asymptomatic HIV-Infected Patients"],"prefix":"10.1177","volume":"29","author":[{"given":"Guillermo","family":"Isasti","sequence":"first","affiliation":[{"name":"Virgen de la Victoria University Hospital","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Moreno","sequence":"additional","affiliation":[{"name":"Virgen de la Victoria University Hospital","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Virgen de la Victoria University Hospital","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Virgen de la Victoria University Hospital","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Palacios","sequence":"additional","affiliation":[{"name":"Virgen de la Victoria University Hospital","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Santos","sequence":"additional","affiliation":[{"name":"Virgen de la Victoria University Hospital","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13802-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000031704.78200.59"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200304001-00007"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.3.9117037"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f7cd42"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1668OC"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03286.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000327514.60879.47"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328331c65e"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200704-541OC"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.5.1268"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/383037"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328310161f"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2008.00602.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp297"},{"key":"e_1_3_2_17_2","first-page":"253","volume-title":"Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels","author":"The Criteria Committee of the New York Heart Association","year":"1994","unstructured":"The Criteria Committee of the New York Heart Association. 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