{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:09:54Z","timestamp":1779106194448,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>\n                    Unconjugated hyperbilirubinemia resulting from therapy with atazanavir is physiologically related to hyperbilirubinemia in Gilbert's syndrome (GS). In patients with GS, changes in diet have a significant impact on bilirubinemia. Our aim was to investigate whether changes in diet affect the level of serum bilirubin in patients receiving atazanavir. Thirty patients on stable therapy with ritonavir-boosted atazanavir without evidence of GS were enrolled. Hemolysis and chronic hepatitis were excluded. After a baseline period of normal intake of calories, the patients were randomized to follow a 24-h 400-calorie diet (fasting), then a 48-h period of normal calorie intake and, afterward, a 24-h period of a high-calorie diet, or the same interventions in inverse order. Serum bilirubin concentrations were measured before and after each intervention. A high adherence to the recommended diet was observed. The mean unconjugated bilirubin concentration before the high-calorie diet was 2.79\u00b11.53\u2009mg\/dl and after such intervention it was 2.70\u00b11.40\u2009mg\/dl. The mean difference between preintervention and postintervention was \u22120.08\u00b10.69\u2009mg\/dl (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =NS). The mean unconjugated bilirubin concentration before the fasting diet was 2.31\u00b11.23\u2009mg\/dl and it was 3.84\u00b11.90\u2009mg\/dl after. The mean difference between prefasting and postfasting was 1.53\u00b11.17\u2009mg\/dl (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.001). According to these results, short periods of fasting seem to increase the unconjugated bilirubin concentration in patients on atazanavir. A high-calorie diet did not have any impact in bilirubin probably because most patients follow similar diets in their everyday life.\n                  <\/jats:p>","DOI":"10.1089\/aid.2012.0232","type":"journal-article","created":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T11:07:38Z","timestamp":1351681658000},"page":"456-460","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Short Communication: Fasting Increases Serum Concentrations of Bilirubin in Patients Receiving Atazanavir: Results from a Pilot Study"],"prefix":"10.1177","volume":"29","author":[{"given":"Gustavo","family":"Lopardo","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n del Centro de Estudios Infectol\u00f3gicos","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiliano","family":"Bissio","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n del Centro de Estudios Infectol\u00f3gicos","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Espinola","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n del Centro de Estudios Infectol\u00f3gicos","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Gallego","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n del Centro de Estudios Infectol\u00f3gicos","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Stambullian","sequence":"additional","affiliation":[{"name":"Helios Salud","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adri\u00e1n","family":"Gadano","sequence":"additional","affiliation":[{"name":"Hospital Italiano de Buenos Aires","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91266-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511023331802"},{"key":"e_1_3_3_4_2","unstructured":"Panel on Antiretroviral Guidelines for Adults Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults adolescents. 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