{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:44:44Z","timestamp":1777380284914,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>\n                    We previously reported mother-to-child transmission of HIV-1 in nine (6.7%) of 135 children on nevirapine prophylaxis in Vietnam. In the current study, we investigated the appearance and profile of antiretroviral drug (ARV) resistance mutations, the predicted coreceptor usage, and the genetic diversity of HIV-1 strains isolated from the eight pairs of HIV-1-infected mothers and their children, who were followed up to 12 months after birth. Portions of the\n                    <jats:italic toggle=\"yes\">pol<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">env<\/jats:italic>\n                    C2V3 regions of the HIV-1 strains were analyzed genetically. HIV-1 CRF01_AE RNA was detected in four (50%) children at delivery. Y181C, a nevirapine resistance mutation, appeared in two (25%) children 1 and 3 months after birth, respectively. No ARV resistance mutation was detected in the mothers, though three mothers were on ARV prophylaxis. Five mothers and their children harbored CCR5-tropic (R5) viruses. Two mothers harbored both R5 and CXCR4-tropic (X4) viruses, but their children harbored only R5 viruses even though the X4 viruses were dominant in the mothers. In the remaining one mother, HIV-1 RNA was not amplified and her child harbored both R5 and X4 viruses at birth, but only X4 virus 12 months after delivery. The infants' viruses were more homogeneous than their mothers' viruses (mean distance: 0.5% vs. 1.1%, respectively). This is the first molecular epidemiological study of vertical HIV-1 infections in Vietnam. These findings may provide useful knowledge for the prevention of mother-to-child transmission of HIV-1 and the antiretroviral treatment of children in Vietnam.\n                  <\/jats:p>","DOI":"10.1089\/aid.2014.0335","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T09:57:49Z","timestamp":1427882269000},"page":"797-805","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic Analyses of HIV-1 Strains Transmitted from Mother to Child in Northern Vietnam"],"prefix":"10.1177","volume":"31","author":[{"given":"Chung Thi Thu","family":"Phan","sequence":"first","affiliation":[{"name":"Kanazawa University","place":["Japan"]},{"name":"National Hospital of Pediatrics","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung Viet","family":"Pham","sequence":"additional","affiliation":[{"name":"Kanazawa University","place":["Japan"]},{"name":"National Hospital of Pediatrics","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuqiong","family":"Bi","sequence":"additional","affiliation":[{"name":"Kanazawa University","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azumi","family":"Ishizaki","sequence":"additional","affiliation":[{"name":"Kanazawa University","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilda","family":"Saina","sequence":"additional","affiliation":[{"name":"Kanazawa University","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cam Dac","family":"Phung","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dung Thi Khanh","family":"Khu","sequence":"additional","affiliation":[{"name":"National Hospital of Pediatrics","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ichimura","sequence":"additional","affiliation":[{"name":"Kanazawa University","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,8,1]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"UNAIDS\/WHO: Global report: UNAIDS report on the global AIDS epidemic 2012. 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