{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:44:53Z","timestamp":1777380293319,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>\n                    The most common antiretroviral treatment (ART) received by individuals infected with HIV-1 in China is the combination therapy, comprised of nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs). To assess the prevalence of HIV-1 drug resistance and subtypes in Honghe of Yunnan, China, patient plasmas from ART-failed individuals were collected from January 2010 to December 2012. Genotyping was conducted using an in-house assay on patient plasmas. A total of 254\n                    <jats:italic toggle=\"yes\">pol<\/jats:italic>\n                    sequences were obtained. The prevalence of drug resistance was 47.2% in ART-failed individuals. Of these drug-resistant individuals, 51.7% harbored HIV strains dually resistant to NRTIs and NNRTIs or protease inhibitors (PIs) (34.2% for NNRTIs and 14.2% for NRTIs). Mutations such as M184V, A62V, T69Ins, K103N, Y181C, and G190A were common among the ART-failed individuals. The frequencies of M184V, A62V, and K103N were 20.5%, 11.0%, and 23.6%, respectively. The most common subtypes in Honghe were CRF08_BC (68.50%) and CRF07_BC (12.20%). The subtypes were almost consistent in different time points for one individual. When receiving ART for 6\u201312 months, the frequency of HIV-1 drug-resistant variants ranked first. This study shows that the high prevalence of HIV drug resistance observed among the ART-failed individuals should be of increasing concern (monitoring of resistance mutations) in ART regions and facilitate developing novel strategies for prevention and control of HIV infection in China.\n                  <\/jats:p>","DOI":"10.1089\/aid.2014.0348","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T13:04:38Z","timestamp":1430226278000},"page":"822-829","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Genetic Diversity and Drug Resistance Among Antiretroviral Treatment-Failed Individuals from 2010 to 2012 in Honghe, China"],"prefix":"10.1177","volume":"31","author":[{"given":"Cuixian","family":"Yang","sequence":"first","affiliation":[{"name":"The Third Military Medical School","place":["China"]},{"name":"CPLA Kunming General Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaomin","family":"Yang","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Hospital of Infectious Disease","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjian","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Hospital of Infectious Disease","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bihui","family":"Yang","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Hospital of Infectious Disease","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiafa","family":"Liu","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Hospital of Infectious Disease","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiqin","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Hospital of Infectious Disease","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongqi","family":"Bian","sequence":"additional","affiliation":[{"name":"The Third Military Medical School","place":["China"]},{"name":"CPLA Kunming General Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,8,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.10.002"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-382"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-242"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm515"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/648729"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065337"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2008.0273"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.23.10958-10964.2000"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181c7d6ff"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.01.004"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072630"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2012.0164"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-012-1557-7"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054917"},{"key":"e_1_3_3_16_2","first-page":"14","volume-title":"China Free ART Manual","author":"Zhang FJ","year":"2005","unstructured":"Zhang FJ: China Free ART Manual. 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