{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:44:36Z","timestamp":1777380276563,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>We report a unique HIV-1 recombinant strain (URF) from an HIV-positive man who has sex with men (MSM) in Beijing, China. This virus genome has insertions and multiple drug-resistant mutations to both nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs), as well as a complex intersubtype recombinant structure with 11 breakpoints. Phylogenetic analysis of the near full-length genome (NFLG) shows that this URF is comprised of gene regions originating from three circulating viral strains: CRF01_AE, subtype B, and subtype C. The parental CRF01_AE regions of the recombinant cluster with a previously described cluster 4 sublineage of CRF01_AE. The B regions of the recombinant cluster within the B (United States\u2013European origin) subtype and the three subtype C regions cluster with a strain detected in China in 1998. The detection and characterization of this complex drug-resistant URF indicate an ongoing generation of recombinant strains among MSM, and will help to provide insight into our understanding of the dynamics and complexity of the HIV-1 epidemic in China.<\/jats:p>","DOI":"10.1089\/aid.2015.0064","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T07:18:52Z","timestamp":1431415132000},"page":"745-748","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["CRF01_AE\/B\/C, a Novel Drug-Resistant HIV-1 Recombinant in Men Who Have Sex with Men in Beijing, China"],"prefix":"10.1177","volume":"31","author":[{"given":"Jing","family":"Yan","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruolei","family":"Xin","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Control and Prevention","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Feng","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Lu","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Control and Prevention","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingjie","family":"Liao","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Ruan","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Shao","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Xing","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.12.001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2011.0196"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13690-2"},{"key":"e_1_3_3_5_2","first-page":"328","article-title":"A survey of the characteristics and STD\/HIV infection of homosexuality in Shenzhen","volume":"32","author":"Cai WD","year":"2005","unstructured":"Cai WD, , Tan JG, , Chen L, et al.: A survey of the characteristics and STD\/HIV infection of homosexuality in Shenzhen. 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