{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:41:57Z","timestamp":1777380117539,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>\n                    We investigated the Th1 protective and regulatory T and B cell (Treg and Breg) responses to pH1N1 monovalent influenza vaccine (IIV1) in HIV-infected pregnant women on combination antiretroviral therapy (cART). Peripheral blood mononuclear cells (PBMCs) from 52 study participants were cryopreserved before and after vaccination and analyzed by flow cytometry. pH1N1-specific Th1, Treg, and Breg responses were measured in PBMCs after\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    stimulation with pH1N1 and control antigen. The cohort analysis did not detect changes in pH1N1-Th1, Treg, or Breg subsets postvaccination. However, individual analyses distinguished subjects who mounted vigorous Th1 responses postvaccination from others who did not. Postvaccination, high pH1N1-Th1 correlated with high pH1N1-Treg and Breg responses, suggesting that low influenza effector responses did not result from excessive vaccine-induced immune regulation. High postvaccination pH1N1-Th1 responses correlated with baseline high PHA- and pH1N1-IFN-\u03b3 ELISpot and circulating CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD39\n                    <jats:sup>+<\/jats:sup>\n                    % and CD8\n                    <jats:sup>+<\/jats:sup>\n                    CD39\n                    <jats:sup>+<\/jats:sup>\n                    % Treg, with low CD8\n                    <jats:sup>+<\/jats:sup>\n                    cell numbers and CD19\n                    <jats:sup>+<\/jats:sup>\n                    FOXP3\n                    <jats:sup>+<\/jats:sup>\n                    % Breg, but not with CD4\n                    <jats:sup>+<\/jats:sup>\n                    cell numbers or HIV viral load. These data highlight the heterogeneity of T cell responses to vaccines in HIV-infected individuals on cART. Predictors of robust Th1 responses to IIV include CD8\n                    <jats:sup>+<\/jats:sup>\n                    cell numbers, T cell functionality, and circulating Breg and Treg.\n                  <\/jats:p>","DOI":"10.1089\/aid.2015.0151","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T13:01:09Z","timestamp":1441026069000},"page":"1170-1177","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Heterogeneity of T Cell Responses to Pandemic pH1N1 Monovalent Vaccine in HIV-Infected Pregnant Women"],"prefix":"10.1177","volume":"31","author":[{"given":"Adriana","family":"Weinberg","sequence":"first","affiliation":[{"name":"University of Colorado Anschutz Medical Campus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petronella","family":"Muresan","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Richardson","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Campus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence","family":"Fenton","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Dominguez","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Campus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Bloom","sequence":"additional","affiliation":[{"name":"Frontier Science and Technology Research Foundation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Heather","family":"Watts","sequence":"additional","affiliation":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Abzug","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Campus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon A.","family":"Nachman","sequence":"additional","affiliation":[{"name":"State University of New York Health Science Center at Stony Brook"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myron J.","family":"Levin","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Campus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the P1086 Study Team","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,11,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis360"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181e46308"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq004"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182a73ebb"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182367662"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu186"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir661"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.01.136"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit057"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122431"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis330"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017739"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis684"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/315323"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01069-10"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/655469"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01812-10"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300954"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2612"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.04.033"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400504"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089236"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028118"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003319"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31817bbea5"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit643"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-323162"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328360c7f3"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200694"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305133"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200690"}],"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2015.0151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/aid.2015.0151","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2015.0151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:16:28Z","timestamp":1777367788000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/aid.2015.0151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1089\/aid.2015.0151"],"URL":"https:\/\/doi.org\/10.1089\/aid.2015.0151","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11]]}}}