{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:22:47Z","timestamp":1791901367194,"version":"4.3.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>\n                    For this study, 50 HIV-1 plasma samples of recently infected men who have sex with men (MSM) were amplified and sequenced. Multiple subtypes were identified by phylogenetic analyses of HIV-1\n                    <jats:italic toggle=\"yes\">gag<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">env<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">pol<\/jats:italic>\n                    gene regions, including CRF01_AE (56.0%), CRF07_BC (30.0%), subtype B (12.0%), and unique recombinant forms (URFs, 6.0%). CRF01_AE was the most frequent genotype in the epidemic. Three recombination patterns of URFs were identified: 01BC, 01B, and 01C. The rate of HIV-1 transmitted drug resistance (TDR) mutation (M46L) was 2.08% (1\/48). URFs and TDR first identified in this study suggest that HIV-1 prevalence is more and more complicated, and HIV-1 drug-resistant strains have begun to spread among at risk populations in Hebei. Our findings can provide vital information for an efficient surveillance system and strategic HIV prevention and control measures in China by revealing the evolutionary status and HIV-1 TDR of HIV-1 strains among recently infected MSM in Hebei Province.\n                  <\/jats:p>","DOI":"10.1089\/aid.2015.0160","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T09:25:27Z","timestamp":1437557127000},"page":"1038-1045","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["HIV-1 Genetic Diversity and Transmitted Drug Resistance Among Recently Infected Individuals at Men Who Have Sex with Men Sentinel Surveillance Points in Hebei Province, China"],"prefix":"10.1177","volume":"31","author":[{"given":"Xinli","family":"Lu","sequence":"first","affiliation":[{"name":"Hebei University","place":["People's Republic of China"]},{"name":"Hebei Province Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjiang","family":"Kang","sequence":"additional","affiliation":[{"name":"Hebei University","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Hebei Province Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongru","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hebei Province Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjian","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Microbiology and Epidemiology","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hebei Province Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hebei Province Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Institute of Microbiology and Epidemiology","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Cui","sequence":"additional","affiliation":[{"name":"Hebei Province Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,10,1]]},"reference":[{"issue":"16","key":"e_1_3_3_2_2","first-page":"3153","article-title":"Analysis on the HIV\/AIDS epidemic in Shijiazhuang","volume":"37","author":"Liu SJ","year":"2010","unstructured":"Liu SJ, , Liu LH, , Dang J, et al.: Analysis on the HIV\/AIDS epidemic in Shijiazhuang. Modern Prevent Med, 2010; 37(16):3153\u20133154.","journal-title":"Modern Prevent Med"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/135965350801302S03"},{"issue":"4","key":"e_1_3_3_4_2","first-page":"399","article-title":"Subtype analysis of the gag and env genes for HIV- 1 strains isolated from different population groups in Hebei province","volume":"17","author":"Zhao CY","year":"2011","unstructured":"Zhao CY, , Li QM, , Li BJ, et al.: Subtype analysis of the gag and env genes for HIV- 1 strains isolated from different population groups in Hebei province. Chin J AIDS STD, 2011; 17(4):399\u2013401.","journal-title":"Chin J AIDS STD"},{"issue":"2","key":"e_1_3_3_5_2","first-page":"264","article-title":"Analysis on drug resistance of human immunodeficiency virus by means of gene detection","volume":"22","author":"Lu XL","year":"2012","unstructured":"Lu XL, , Zhao HR, , Zhao CY, et al.: Analysis on drug resistance of human immunodeficiency virus by means of gene detection. Chin J Health Lab Technol, 2012; 22(2):264\u2013266.","journal-title":"Chin J Health Lab Technol"},{"key":"e_1_3_3_6_2","first-page":"72","article-title":"The genetic variation and molecular evolution study on HIV-1 strains circulated in Yunnan Province and quasispecies during early HIV-1 infection","author":"Liu YJ","year":"2011","unstructured":"Liu YJ: The genetic variation and molecular evolution study on HIV-1 strains circulated in Yunnan Province and quasispecies during early HIV-1 infection. Acad Military Med Sci, 2011; 72\u201378.","journal-title":"Acad Military Med Sci"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0956462414543841"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/088922202320935410"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2014.12.012"},{"issue":"7","key":"e_1_3_3_10_2","first-page":"533","article-title":"Subtyping and sequence analysis of the C2-V3 region of gp120 genes among HIV-1 strains in Hebei province","volume":"25","author":"Zhao CY","year":"2005","unstructured":"Zhao CY, , Xing H, , Zhao HR, et al.: Subtyping and sequence analysis of the C2-V3 region of gp120 genes among HIV-1 strains in Hebei province. Chin J Microbiol Immunol, 2005; 25(7):533\u2013535.","journal-title":"Chin J Microbiol Immunol"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2011.05.017"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004724"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/135965350801302S10"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3290(06)60225-2"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-012-1557-7"}],"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2015.0160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/aid.2015.0160","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2015.0160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:16:24Z","timestamp":1777367784000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/aid.2015.0160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1089\/aid.2015.0160"],"URL":"https:\/\/doi.org\/10.1089\/aid.2015.0160","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10]]}}}