{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:48:09Z","timestamp":1777380489625,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1089\/aid.2015.0359","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T22:14:06Z","timestamp":1460412846000},"page":"909-917","source":"Crossref","is-referenced-by-count":3,"title":["Novel Mutations L228I and Y232H Cause Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Combinational Pattern"],"prefix":"10.1177","volume":"32","author":[{"given":"Xiao-Min","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biosafety Level-3 Laboratory, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China."},{"name":"Guangzhou Center for Disease Control and Prevention, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terrence Chi-Kong","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hin","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Yan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Jian","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709113371101"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709113371102"},{"key":"B3","volume-title":"Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection: Recommendations for a Public Health Approach","author":"World Health Organization","year":"2013"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2165\/11633630-000000000-00000"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2012.09.021"},{"key":"B6","first-page":"98","volume":"8","author":"Holguin A","year":"2006","journal-title":"AIDS Rev"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200301030-00001"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0487"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011812810397"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200404090-00008"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00829-10"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg079"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.2174\/157016212799937236"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2013.0211"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03415.x"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku565"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.2.1012-1019.2004"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.40.28175"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.17.11157"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1021\/bi952773j"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20500"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200304110-00003"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00592-09"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.28.17581"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031233"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006108"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044333"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835d9f6d"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01795-09"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00870-09"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku487"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti770"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00303-07"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt012"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093804"},{"key":"B36","first-page":"215","volume":"3","author":"Bahman MK","year":"2008","journal-title":"Iranian J Clin Infect Dis"},{"key":"B37","first-page":"119","volume":"15","author":"Johnson VA","year":"2007","journal-title":"Top HIV Med"},{"key":"B38","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/135965350901400114","volume":"14","author":"Tambuyzer L","year":"2009","journal-title":"Antivir Ther"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2013.0211"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.2174\/1570162043351093"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20061814"},{"key":"B42","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1124\/mol.105.012351","volume":"68","author":"Auwerx J","year":"2005","journal-title":"Mol Pharmacol"},{"key":"B43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1124\/mol.105.012435","volume":"68","author":"Balzarini J","year":"2005","journal-title":"Mol Pharmacol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.16.10718-10729.2005"}],"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/aid.2015.0359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:17:33Z","timestamp":1777367853000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/aid.2015.0359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1089\/aid.2015.0359"],"URL":"https:\/\/doi.org\/10.1089\/aid.2015.0359","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9]]}}}