{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:16:35Z","timestamp":1778685395785,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>\n                    Antiretroviral (ARV) resistance mutations in human immunodeficiency virus type 1 (HIV-1) infection may reduce the efficacy of prophylactic therapy to prevent mother-to-child transmission (PMTCT) and future treatment options. This study evaluated the diversity and the prevalence of transmitted drug resistance (TDR) in protease (PR) and reverse transcriptase (RT) regions of HIV-1\n                    <jats:italic toggle=\"yes\">pol<\/jats:italic>\n                    gene among 87 ARV-naive HIV-1-infected pregnant women from Rio de Janeiro, Brazil, between 2012 and 2015. The viral diversity comprised HIV-1 subtypes B (67.8%), F1 (17.2%), and C (4.6%); the circulating recombinant forms 12_BF (2.3%), 28\/29_BF, 39_BF, 02_AG (1.1% each) and unique recombinants forms (4.5%). The overall prevalence of any TDR was 17.2%, of which 5.7% for nucleoside RT inhibitors, 5.7% for non-nucleoside RT inhibitors, and 8% for PR inhibitors. The TDR prevalence found in this population may affect the virological outcome of the standard PMTCT ARV-regimens, reinforcing the importance of continuous monitoring.\n                  <\/jats:p>","DOI":"10.1089\/aid.2016.0159","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T22:24:11Z","timestamp":1468016651000},"page":"68-73","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["High HIV-1 Diversity and Prevalence of Transmitted Drug Resistance Among Antiretroviral-Naive HIV-Infected Pregnant Women from Rio de Janeiro, Brazil"],"prefix":"10.1177","volume":"33","author":[{"given":"Edson","family":"Delatorre","sequence":"first","affiliation":[{"name":"Instituto Oswaldo Cruz\u2013FIOCRUZ","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Silva-de-Jesus","sequence":"additional","affiliation":[{"name":"Instituto Oswaldo Cruz\u2013FIOCRUZ","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Carlos","family":"Couto-Fernandez","sequence":"additional","affiliation":[{"name":"Instituto Oswaldo Cruz\u2013FIOCRUZ","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose H.","family":"Pilotto","sequence":"additional","affiliation":[{"name":"Instituto Oswaldo Cruz\u2013FIOCRUZ","place":["Brazil"]},{"name":"Hospital Geral de Nova Igua\u00e7u","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariza G.","family":"Morgado","sequence":"additional","affiliation":[{"name":"Instituto Oswaldo Cruz\u2013FIOCRUZ","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"UNAIDS. 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