{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:48:53Z","timestamp":1777380533991,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>This Special Issue of AIDS Research and Human Retroviruses features results from the HIV Cure Initiative, funded by the California HIV\/AIDS Research Program (CHRP). As a publicly funded grant maker, CHRP has served for more than three decades as a unique resource for innovative researchers in California, whose work seeks to address all aspects of the HIV epidemic and the communities affected by it. Early initiatives at CHRP pioneered what would become enduring cornerstones of HIV science: isolation of the virus; efficacy and toxicities of the first HIV treatments; the emergence of drug resistance; the first biospecimen banks for HIV-related research; the first community-based laboratory service for HIV diagnostic serology; and the first longitudinal case-control study of progression from HIV to AIDS\u2014The San Francisco General Hospital Cohort. More recently, CHRP-funded conceptual studies of zinc-finger nuclease-mediated disruption of CCR5 genomic sequences and the safety of solid organ transplantation for HIV-positive patients have progressed from brilliant ideas to clinical realities, and CHRP is currently funding the first multisite trial of HIV preexposure prophylaxis for transgender persons in the United States. The present article outlines the founding of CHRP, our current grantmaking process, and our impact on HIV research over time. In 2013, CHRP launched a new initiative aimed at moving the then nascent frontier of HIV cure science forward: the CHRP HIV Cure Initiative provided over $1.4 million to multiple basic biomedical research projects, and selected results are presented in this Special Issue.<\/jats:p>","DOI":"10.1089\/aid.2017.0149","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T01:43:32Z","timestamp":1504057412000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The California HIV\/AIDS Research Program: History, Impact, and HIV Cure Initiative"],"prefix":"10.1177","volume":"33","author":[{"given":"Lisa Loeb","family":"Stanga","sequence":"first","affiliation":[{"name":"University of California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwer","family":"Mujeeb","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Packel","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler","family":"Martz","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Lemp","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,11,1]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"250","article-title":"Pneumocystis pneumonia\u2014Los Angeles","volume":"30","author":"Centers for Disease Control (CDC)","year":"1981","unstructured":"Centers for Disease Control (CDC): Pneumocystis pneumonia\u2014Los Angeles. 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California HIV\/AIDS Policy Research Centers, California, 2016."},{"key":"e_1_3_3_20_2","volume-title":"AIDS Drug Assistance Program Fiscal Year 2017\u20132018 May Revision Estimate","author":"Smith KL","year":"2017","unstructured":"Smith KL: AIDS Drug Assistance Program Fiscal Year 2017\u20132018 May Revision Estimate. California Department of Public Health, California, 2017."},{"key":"e_1_3_3_21_2","unstructured":"California HIV\/AIDS Policy Research Centers: The Use of HIV Over-The-Counter (OTC) Test in California from April to September 2013. Policy Briefs May 2014."},{"key":"e_1_3_3_22_2","volume-title":"HIV Criminalization in California: Penal Implications for People Living with HIV\/AIDS","author":"Hasenbush A","year":"2015","unstructured":"Hasenbush A, , Miyashita A, , Wilson BDM: HIV Criminalization in California: Penal Implications for People Living with HIV\/AIDS. 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