{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:31:42Z","timestamp":1777379502991,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>\n                    Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate-emtricitabine (TDF-FTC) reduces bone mineral density in HIV-uninfected men who have sex with men (MSM). We hypothesized that PrEP with TDF-FTC would increase bone turnover markers (BTMs) at week 24 and that vitamin D supplementation from weeks 24 to 48 would blunt this increase. Participants were from a cohort of 398 MSM and transgender women who received daily TDF-FTC for PrEP. At week 24, a prospective intervention group initiated vitamin D3 4,000 IU daily. Concurrent controls were selected from the cohort who took \u2264400 IU\/day of vitamin D3 matched by age, race, and body mass index. The primary endpoint was the change in procollagen-I N-terminal propeptide (P1NP) from weeks 24 to 48. Paired\n                    <jats:italic toggle=\"yes\">t<\/jats:italic>\n                    -tests were used to compare changes in BTMs between intervention and controls. Among 48 intervention\u2013control pairs, median age was 33 years. At baseline, 68.9% of the intervention group and 77.3% of controls were vitamin D sufficient (\u226520\u2009ng\/mL,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.94). P1NP, C-telopeptide, parathyroid hormone (PTH), and 25-OH vitamin D3 did not increase significantly at week 24. P1NP fell by a mean\u2009\u00b1\u2009SD of \u221227.6\u2009\u00b1\u200949.9\u2009pg\/mL from weeks 24 to 48 with vitamin D and \u22122.5\u2009\u00b1\u200940.2\u2009pg\/mL in controls (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.01). There were no significant between-group differences in the weeks 24\u201348 change in C-telopeptide, PTH, or 25-OH vitamin D3. Vitamin D3 supplementation with 4,000 IU\/day resulted in a significant reduction in the BTM P1NP compared with controls, suggesting that this intervention has potential to improve bone health during PrEP.\n                  <\/jats:p>","DOI":"10.1089\/aid.2018.0280","type":"journal-article","created":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T05:37:14Z","timestamp":1553319434000},"page":"608-614","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Vitamin D Supplementation on Bone Turnover Markers During HIV Pre-Exposure Prophylaxis Using Tenofovir Disoproxil Fumarate-Emtricitabine in Men Who Have Sex with Men"],"prefix":"10.1177","volume":"35","author":[{"given":"Deepa D.","family":"Nanayakkara","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Public Health, University of California at San Diego, San Diego, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheldon","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Public Health, University of California at San Diego, San Diego, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stan","family":"Louie","sequence":"additional","affiliation":[{"name":"University of Southern California School of Pharmacy, Los Angeles, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Mulligan","sequence":"additional","affiliation":[{"name":"University of California at San Francisco, San Francisco, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turner","family":"Overton","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Asante","sequence":"additional","affiliation":[{"name":"University of Southern California School of Pharmacy, Los Angeles, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katya","family":"Corado","sequence":"additional","affiliation":[{"name":"Division of HIV Medicine, Harbor-UCLA Medical Center, Torrance, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Public Health, University of California at San Diego, San Diego, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Dub\u00e9","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, California."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835192ae"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.2.191"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir188"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090111"},{"key":"e_1_3_3_6_2","first-page":"287","article-title":"Bone mineral density changes among young, healthy african women receiving oral tenofovir for HIV preexposure prophylaxis","volume":"71","author":"Mirembe BG","year":"2016","unstructured":"Mirembe BG, , Kelly CW, , Mgodi N, et al.: Bone mineral density changes among young, healthy african women receiving oral tenofovir for HIV preexposure prophylaxis. JAIDS, 2016; 71:287\u2013294.","journal-title":"JAIDS"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.14423\/SMJ.0000000000000560"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023688"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ324"},{"key":"e_1_3_3_10_2","first-page":"177","article-title":"Brief report: Recovery of bone mineral density after discontinuation of tenofovir-based HIV pre-exposure prophylaxis","volume":"76","author":"Glidden DV","year":"2017","unstructured":"Glidden DV, , Mulligan K, , McMahan V, et al.: Brief report: Recovery of bone mineral density after discontinuation of tenofovir-based HIV pre-exposure prophylaxis. JAIDS, 2017; 76:177\u2013182.","journal-title":"JAIDS"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir968"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044845"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw125"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2755"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01096-13"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1409"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2012.0089"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv239"},{"key":"e_1_3_3_19_2","first-page":"2011","volume-title":"Dietary Reference Intakes for Calcium and Vitamin D","author":"Ross AC","unstructured":"Institute of Medicine Committee to Review Dietary Reference Intakes for Vitamin D, Calcium: The National Academies Collection: Reports funded by National Institutes of Health. In: Dietary Reference Intakes for Calcium and Vitamin D (Ross AC, , Taylor CL, , Yaktine AL, , Del Valle HB, eds.). Washington: DC, National Academies Press (US) National Academy of Sciences, 2011."},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001145"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70847-3"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506273"},{"key":"e_1_3_3_23_2","first-page":"64317","article-title":"Decline in Bone Mass With Tenofovir Disoproxil Fumarate\/Emtricitabine Is Associated With Hormonal Changes in the Absence of Renal Impairment When Used by HIV-Uninfected Adolescent Boys and Young Men for HIV Preexposure Prophylaxis","author":"Havens PL","year":"2017","unstructured":"Havens PL, , Stephensen CB, , Van Loan MD, et al.: Decline in Bone Mass With Tenofovir Disoproxil Fumarate\/Emtricitabine Is Associated With Hormonal Changes in the Absence of Renal Impairment When Used by HIV-Uninfected Adolescent Boys and Young Men for HIV Preexposure Prophylaxis. Clin Infect Dis, 2017; 64317\u2013325.","journal-title":"Clin Infect Dis"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-014-9854-7"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001131"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2011.0052"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181caebaa"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2009.0308"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1310\/hct1306-350"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001545"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix753"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1788"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.3.649"}],"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/aid.2018.0280","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2018.0280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2018.0280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:14:31Z","timestamp":1777367671000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/aid.2018.0280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,26]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1089\/aid.2018.0280"],"URL":"https:\/\/doi.org\/10.1089\/aid.2018.0280","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,26]]}}}