{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:34:51Z","timestamp":1777379691264,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>\n                    We assessed bone mineral density (BMD) in a cohort of human immunodeficiency virus (HIV)-positive patients after a median of 11 years of combination antiretroviral therapy (cART) and evaluated the respective role of HIV infection and antiretroviral drugs (ARVs). A cross-sectional study of 162 participants (131 male) from the ANRS-C08 cohort was performed with bone dual-energy X-ray absorptiometry (DXA) scans and renal assessment. The window of exposure to ARVs was defined as an exposure of more than six cumulative months during the last 3 years before the DXA evaluation to account for a cumulative exposure that could affect bone remodeling. The association with low BMD (Z-score &lt; \u22122) was assessed by a multiple logistic regression model. The study population was 50 years (median), hepatitis C virus (HCV) (18%), and hepatitis B virus (HBV) (8%) coinfection with HIV-RNA &lt;50 c\/mL in 89%, median CD4 of 619\/mm\n                    <jats:sup>3<\/jats:sup>\n                    . Prevalence of low BMD was 18% in males and 6% in females. The factors associated with a Z-score &lt; \u22122 in males were uric acid renal loss [adjusted odds ratio (aOR): 6.1; 95% confidence interval (CI): 1.2\u201331.5;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.03], HCV coinfection (aOR: 4.0; 95% CI: 1.3\u201312.2;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.02), and less frequent window of exposure to nevirapine (NVP) (aOR: 0.1; 95% CI: 0.02\u20130.6;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.01). For the full study sample, there was a strong positive association between duration of exposure to NVP and lumbar spine Z-score (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.004). HIV-positive patients exposed to long-term cART have a high incidence of low BMD. Tenofovir disoproxil fumarate and ritonavir-boosted protease inhibitors did not seem to be associated with increased risk of low BMD, whereas NVP exposure appeared to have an independent positive association.\n                  <\/jats:p>","DOI":"10.1089\/aid.2019.0229","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T18:52:40Z","timestamp":1577818360000},"page":"399-405","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Nevirapine Use Is Associated with Higher Bone Mineral Density in HIV-1 Positive Subjects on Long-Term Antiretroviral Therapy"],"prefix":"10.1177","volume":"36","author":[{"given":"Camille","family":"Couffignal","sequence":"first","affiliation":[{"name":"Infection, Antimicrobials, Modeling, Evolution (IAME) UMR 1137, INSERM and Universit\u00e9 of Paris, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami","family":"Kolta","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital Cochin, Assistance Publique\u2013H\u00f4pitaux de Paris, INSERM UMR-1153, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Flamant","sequence":"additional","affiliation":[{"name":"Department of Physiology, University Hospital Bichat, Assistance Publique\u2013H\u00f4pitaux de Paris, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Cazanave","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital Bordeaux, Bordeaux, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Philippe","family":"Haymann","sequence":"additional","affiliation":[{"name":"Department of Physiology, University Hospital Tenon, and INSERM UMR_S1155, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"France","family":"Mentr\u00e9","sequence":"additional","affiliation":[{"name":"Infection, Antimicrobials, Modeling, Evolution (IAME) UMR 1137, INSERM and Universit\u00e9 of Paris, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Duval","sequence":"additional","affiliation":[{"name":"Infection, Antimicrobials, Modeling, Evolution (IAME) UMR 1137, INSERM and Universit\u00e9 of Paris, Paris, and INSERM CIC1425, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Leport","sequence":"additional","affiliation":[{"name":"Unit\u00e9 COREB (Coordination du Risque Epid\u00e9mique et Biologique), Assistance Publique\u2013H\u00f4pitaux de Paris, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Raffi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital Hotel-Dieu, and INSERM CIC 1413, University of Nantes, Nantes, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ch\u00eane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Salamon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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