{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:33:15Z","timestamp":1777379595441,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2020,11]]},"abstract":"\n Previous studies have shown that HIV-infected individuals were less susceptible to chronic gastritis and\n Helicobacter pylori<\/jats:italic>\n infection. Th1 and Th17 cells are important components of the immune response to\n H. pylori<\/jats:italic>\n in adults. We investigated the relative importance of Th1 versus Th17 responses for mucosal inflammation and protection. We conducted a prospective cross-sectional study to evaluate the relationship among the peripheral blood gut-homing CD4\n +<\/jats:sup>\n T cell subset, the severity of chronic\n H. pylori<\/jats:italic>\n gastritis, and\n H. pylori<\/jats:italic>\n amount in the gastric mucosa. Biopsy specimens were obtained at the time of gastroendoscopy, which was used for classification of histological gastritis by updated-Sydney system. Peripheral blood mononuclear cells were collected at the same point to determine the frequency of peripheral blood gut homing CD4\n +<\/jats:sup>\n T cells (CCR9\n +<\/jats:sup>\n integrin \u03b2\n 7<\/jats:sub>\n +<\/jats:sup>\n ) and CD4\n +<\/jats:sup>\n memory T cells subsets by flow cytometry.\n H. pylori<\/jats:italic>\n amount in the gastric mucosa was measured using 16S ribosomal RNA gene amplicon sequencing. Peripheral blood gut-homing CD4\n +<\/jats:sup>\n T cells were significantly higher in individuals with histological gastritis compared with those without chronic gastritis (median 16.8 cells\/\u03bcL vs. 9.7 cells\/\u03bcL;\n p<\/jats:italic>\n \u2009=\u2009.0307). In particular, there were significant differences in gut-homing Th1 (median 1.3 cells\/\u03bcL vs. 0.5 cells\/\u03bcL;\n p<\/jats:italic>\n \u2009=\u2009.0061) and nonconventional Th1 (median 0.4 cells\/\u03bcL vs. 0.2 cells\/\u03bcL;\n p<\/jats:italic>\n \u2009=\u2009.0196). In addition, there was a significant positive correlation between\n H. pylori<\/jats:italic>\n amount in the gastric mucosa measured using 16S ribosomal RNA gene amplicon sequencing and gut-homing Th1 subsets. Our findings suggested that gut Th1 may play a key role in the development of chronic gastritis in HIV-infected individuals.\n <\/jats:p>","DOI":"10.1089\/aid.2020.0086","type":"journal-article","created":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T01:11:21Z","timestamp":1595639481000},"page":"910-917","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Gut-Homing CD4\n +<\/sup>\n T Cells Are Associated with the Activity of Gastritis in HIV-Infected Adults"],"prefix":"10.1177","volume":"36","author":[{"given":"Hidenori","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of The Institute of Medical Science, The University of Tokyo, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Pathology, IMSUT Hospital of The Institute of Medical Science, The University of Tokyo, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutoshi","family":"Kido","sequence":"additional","affiliation":[{"name":"Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Oita, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Oita, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Division of Advanced Genome Medicine, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Matano","sequence":"additional","affiliation":[{"name":"AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Hirata","sequence":"additional","affiliation":[{"name":"Division of Advanced Genome Medicine, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Kawana-Tachikawa","sequence":"additional","affiliation":[{"name":"AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Yamaoka","sequence":"additional","affiliation":[{"name":"Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Oita, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yotsuyanagi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of The Institute of Medical Science, The University of Tokyo, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisuke","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of The Institute of Medical Science, The University of Tokyo, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60604-8"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12131"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3016"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i7.976"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.9.4594-4602.1999"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03513"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030484"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01726"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/656722"},{"key":"e_1_3_5_11_2","first-page":"1161","article-title":"Classification and grading of gastritis","volume":"20","author":"Dixon MF","year":"1996","unstructured":"Dixon MF, , Genta RM, , Yardley JH, , Correa P: Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol, 1996; 20:1161\u20131181.","journal-title":"The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59011"},{"key":"e_1_3_5_13_2","first-page":"400","article-title":"T cell immunity","volume":"347","author":"Becattini S","year":"2015","unstructured":"Becattini S, , Latorre D, , Mele F, et al.: T cell immunity. Functional heterogeneity of human memory CD4(+) T cell clones primed by pathogens or vaccines. Science, 2015; 347:400\u2013406.","journal-title":"Functional heterogeneity of human memory CD4(+) T cell clones primed by pathogens or vaccines. 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