{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:10:04Z","timestamp":1785330604225,"version":"3.55.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>\n                    In HIV-infected patients, antiretroviral therapy (ART) is associated to adipose tissue redistribution known as lipodystrophy (LD). This study aimed at verifying the association between the polymorphism of the\n                    <jats:italic toggle=\"yes\">MMP1<\/jats:italic>\n                    gene (rs1799750) (1G\/2G) and the serum levels of matrix metalloproteinase 1 (MMP-1) with LD and its subtypes in people living with HIV on ART. This is a cross-secional study. LD was self-reported. The determination of the\n                    <jats:italic toggle=\"yes\">MMP1<\/jats:italic>\n                    rs1799750 gene polymorphism was performed by real-time PCR, and the serum concentrations of MMP-1 were quantified by the enzyme-linked immunosorbent assay (ELISA) method. Of 404 participants, 204 (51%) were diagnosed with LD, of whom 89 (43%) had mixed lipodystrophy (ML), 72 (35%) had lipohypertrophy (LH), and 43 (22%) had lipoatrophy (LA). There was an association between the genotypes 1G\/1G+1G\/2G and higher serum levels of MMP-1 (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.025). There was no association of\n                    <jats:italic toggle=\"yes\">MMP1<\/jats:italic>\n                    (1G\/2G) with LD. Other factors associated with LD were current CD4\u2009\u2264\u2009350 [odds ratio (OR)\u2009=\u20094.85, confidence interval (CI)\u2009=\u20091.78\u201347.99,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.0033] and serum MMP-1 levels &gt;6.81 (OR\u2009=\u20092.67, CI\u2009=\u20091.21\u20136.08,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.0165). Factors associated with ML: current CD4\u2009\u2264\u2009350 (OR\u2009=\u20095.59, CI\u2009=\u20091.69\u201320.39,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.006); with LH: number of antiretroviral regimens used: 2 (OR\u2009=\u20092.06, CI\u2009=\u20091.01\u20134.20,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.0460) and 3+ (OR\u2009=\u20092.09, CI\u2009=\u20091.00\u20134.35,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.0477), and current CD4\u2009\u2264\u2009350 (OR\u2009=\u20092.08, CI\u2009=\u20091.00\u20134.24,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.0461); and with LA: current viral load &gt;40 (OR\u2009=\u20092.52, CI\u2009=\u20091.03\u20135.91,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.0372) and current use of zidovudine (OR\u2009=\u20092.97, CI\u2009=\u20091.32\u20136.54,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.0074). Higher levels of MMP-1 were associated with genotypes 1G\/2G+1G\/1G and with LD. Other individual risk factors were independently associated with LD, and its subtypes, suggesting that the pathogenesis itself is differently manifested for each type of LD.\n                  <\/jats:p>","DOI":"10.1089\/aid.2020.0237","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T09:20:03Z","timestamp":1613380803000},"page":"399-406","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The 1G\/1G+1G\/2G Genotypes of\n                    <i>MMP1<\/i>\n                    rs1799750 Are Associated with Higher Levels of MMP-1 and Are Both Associated with Lipodystrophy in People Living with HIV on Antiretroviral Therapy"],"prefix":"10.1177","volume":"37","author":[{"given":"Andreia Soares da","family":"Silva","sequence":"first","affiliation":[{"name":"Faculty of Medical Sciences (FCM), University of Pernambuco (UPE), Recife, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria do Socorro de Mendon\u00e7a","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences (FCM), University of Pernambuco (UPE), Recife, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taciana Furtado de Mendon\u00e7a","family":"Belmont","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences (FCM), University of Pernambuco (UPE), Recife, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Arraes de Alencar","family":"Ximenes","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences (FCM), University of Pernambuco (UPE), Recife, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Vieira da","family":"Silva","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences (FCM), University of Pernambuco (UPE), Recife, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Nascimento da","family":"N\u00f3brega","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es (IAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta dos Santos","family":"Souza","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es (IAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Cristina Cordeiro","family":"Farias","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences (FCM), University of Pernambuco (UPE), Recife, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kleyton Palmeira","family":"do \u00d3","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es (IAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luydson Richardson Silva","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es (IAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Tadeu Nunes","family":"Diniz","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es (IAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dem\u00f3crito de Barros","family":"Miranda-Filho","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences (FCM), University of Pernambuco (UPE), Recife, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.12.001"},{"key":"e_1_3_6_3_2","first-page":"42","article-title":"Distribution of body fat and lipid and glycemic profiles of HIV-infected patients","volume":"51","author":"Guimar\u00e3es MMM","year":"2007","unstructured":"Guimar\u00e3es MMM, , Greco DB, , J\u00fanior ARO, , Penido MG, , Machado LJC: Distribution of body fat and lipid and glycemic profiles of HIV-infected patients. 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