{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:42:05Z","timestamp":1777380125134,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>\n                    Dual compartment suppositories are being developed to prevent HIV and other sexually transmitted infections. Such products, for use in the rectum, the vagina, or both, could have a significant public health impact by decreasing global incidence of these diseases. In this study, 16 women each used two rheologically distinct suppositories in their vagina and rectum. User Sensory Perception and Experience (USPE) scales assessed sensory experiences during sexual activity to understand whether, and how, women perceive formulation properties in the vagina and rectum. Qualitative data from individual in-depth interviews captured women's descriptions and comparisons of the experiences. Significant differences and large Cohen's\n                    <jats:italic toggle=\"yes\">d<\/jats:italic>\n                    effect sizes between vaginal and rectal experiences of suppository-A were found for three scales:\n                    <jats:italic toggle=\"yes\">Application (APP): Product Awareness<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">SEX: Initial Penetration<\/jats:italic>\n                    ; and\n                    <jats:italic toggle=\"yes\">SEX: Effortful<\/jats:italic>\n                    . Qualitative data provided user experience details that credibly align with these score differences. Near significant differences and large effect sizes were found for two additional scales:\n                    <jats:italic toggle=\"yes\">SEX: Perceived Wetness<\/jats:italic>\n                    with suppository-A and\n                    <jats:italic toggle=\"yes\">SEX: Messiness<\/jats:italic>\n                    with suppository-B. In addition, other scale scores showed medium-to-large effect sizes that correspond to hypothesized sensations associated with biophysical properties of the suppositories. Statistical significance combined with large effect sizes and qualitative data accurately represent the hypothesized perceptibility of suppository properties and identifies performance characteristics relevant to acceptability and adherence; together these data provide discernment of factors that can guide the development of dual compartment products.\n                  <\/jats:p>\n                  <jats:p>The Clinical Trial Registration number: NCT02744261.<\/jats:p>","DOI":"10.1089\/aid.2021.0038","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T03:11:23Z","timestamp":1632193883000},"page":"601-610","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Designing Dual Compartment HIV Prevention Products: Women's Sensory Perceptions and Experiences of Suppositories for Rectal and Vaginal Use"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5528-1212","authenticated-orcid":false,"given":"Kate M.","family":"Guthrie","sequence":"first","affiliation":[{"name":"Center for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, Rhode Island, USA."},{"name":"Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA."},{"name":"Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, Rhode Island, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rochelle K.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Center for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, Rhode Island, USA."},{"name":"Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, Rhode Island, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Guillen","sequence":"additional","affiliation":[{"name":"Center for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, Rhode Island, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime J.","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Center for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, Rhode Island, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara E.","family":"Vargas","sequence":"additional","affiliation":[{"name":"Center for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, Rhode Island, USA."},{"name":"Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph L.","family":"Fava","sequence":"additional","affiliation":[{"name":"Center for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, Rhode Island, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony S.","family":"Ham","sequence":"additional","affiliation":[{"name":"ImQuest BioSciences, Frederick, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F.","family":"Katz","sequence":"additional","affiliation":[{"name":"Departments of Bioengineering and Obstetrics and Gynecology, Duke University, Durham, North Carolina, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Cu-Uvin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA."},{"name":"Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Tumilty","sequence":"additional","affiliation":[{"name":"Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelley A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Center for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, Rhode Island, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen W.","family":"Buckheit","sequence":"additional","affiliation":[{"name":"ImQuest BioSciences, Frederick, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":", Jr.","given":"Robert W.","family":"Buckheit","sequence":"additional","affiliation":[{"name":"ImQuest BioSciences, Frederick, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"National Center for HIV\/AIDS. 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