{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:41:24Z","timestamp":1777380084899,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n                    Retention in HIV pre-exposure prophylaxis (PrEP) care and adherence to PrEP have been suboptimal in some populations, despite evidence that high adherence dramatically enhances PrEP efficacy. A comprehensive PrEP Clinic with a retention specialist and clinical pharmacist could impact patient's retention and adherence in PrEP care. A retrospective electronic medical record review of patients attending an academic PrEP Clinic was conducted between June 2018 and June 2019 (at least one visit attended for PrEP was required). Retention was defined as a medical or laboratory visit every 3 months \u00b130 days, as recommended by CDC guidelines, but was analyzed using the number of visits and time between visits via multivariate regression analyses. PrEP adherence was calculated using a Medication-Possession Ratio (MPR) and compared between patient characteristics using Kruskal\u2013Wallis tests. One hundred twenty-two patients were identified by chart review, 96 had sufficient data for follow-up and were included in at least one analysis. The population was primarily cisgender men who have sex with men and over half were African American or Hispanic. Overall, patient retention was 43%. The retention analysis demonstrated that individuals who self-identified as gay were more likely to be retained than those who identified as heterosexual (53% vs. 18%, hazard ratio\u2009=\u20091.75, 95% confidence interval\u2009=\u2009[1.01\u20133.03],\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.045). Although not statistically significant, African Americans and cisgender women were less likely to be retained in care. The adherence analysis identified higher median MPRs among patients not reporting previous incarceration (80% vs. 35%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u2009.01). Although not statistically significant, there was lower adherence among youth 18\u201324 (11% vs. 54% MPR &gt;80,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.058). Despite comprehensive PrEP clinical care, heterosexual individuals were less likely to be retained in PrEP care than those who self-identified as gay and previously incarcerated individuals were less likely to be adherent to PrEP.\n                  <\/jats:p>","DOI":"10.1089\/aid.2021.0130","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T01:20:05Z","timestamp":1638580805000},"page":"327-335","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Factors Associated with Retention and Adherence in a Comprehensive, Diverse HIV Pre-Exposure Prophylaxis Clinic"],"prefix":"10.1177","volume":"38","author":[{"given":"Andrew","family":"Goodman","sequence":"first","affiliation":[{"name":"School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Patten","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Informatics, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Castillo-Mancilla","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanta","family":"Zimmer","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA."},{"name":"Division of Infectious Diseases, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Madinger","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6565-6703","authenticated-orcid":false,"given":"Katherine","family":"Frasca","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"CDC: Preexposure Prophylaxis for the Prevention of HIV Infection in the United States\u20142017 Update: A Clinical Practice Guideline 2017. Available at https:\/\/www.cdc.gov\/hiv\/pdf\/risk\/prep\/cdc-hiv-prep-guidelines-2017.pdf accessed January15 2021."},{"key":"e_1_3_5_3_2","unstructured":"CDC: HIV Basics https:\/\/www.cdc.gov\/hiv\/basics\/statistics.html: CDC; 2018 [cited 2020]. Available at https:\/\/www.cdc.gov\/hiv\/basics\/statistics.html accessed January15 2021."},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000647"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221281"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003174"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004006"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70847-3"},{"key":"e_1_3_5_9_2","unstructured":"RCT: R: A Language and Environment for Statistical Computing. Viena Austria: R Foundation for Statistical Computing. Available at https:\/\/www.R-project.org (2020) accessed January15 2021."},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506273"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy160"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.19.1.20903"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-018-2296-x"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001724"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002506"},{"key":"e_1_3_5_16_2","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1001\/jama.2018.18947","article-title":"PrEP disparities","volume":"320","author":"Kuehn B","year":"2018","unstructured":"Kuehn B: PrEP disparities. JAMA, 2018; 320:2304.","journal-title":"JAMA"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.4172\/2155-6113.1000730"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2017.0201"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205593"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-012-0372-1"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001179"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000613"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy810"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.08.006"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25385"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-017-2009-x"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-019-04958-z"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-020-00502-5"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000216"}],"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/aid.2021.0130","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2021.0130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2021.0130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:16:23Z","timestamp":1777367783000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/aid.2021.0130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1089\/aid.2021.0130"],"URL":"https:\/\/doi.org\/10.1089\/aid.2021.0130","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}