{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:43:59Z","timestamp":1777380239792,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>\n                    Menopause is a high-risk period for osteoporosis, which may be exacerbated by HIV and\/or antiretroviral therapy (ART). Our goal was to study the impact of switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) on bone mineral density (BMD) in peri- and early postmenopausal women living with HIV. This is a randomized international multicenter study of an early versus delayed (48-week) switch. BMD was measured by dual energy X-ray absorptiometry scan. Thirty-four women were enrolled: 19 in the immediate and 15 in the delayed switch arm from September 2017 to April 2019; 30 completed the 96-week protocol. The study closed for futility during the COVID-19 pandemic. The median (intraquartile range [IQR]) age was 51 years (47, 53), with a median (IQR) of 16.5 years (14, 23) since HIV diagnosis, median (IQR) 14 years (11, 20) of ART, and mean 8.6 years TDF. At enrollment, TDF was used in combination with a boosted protease inhibitor (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20097), a non-nucleoside reverse transcriptase inhibitor (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200913), an integrase inhibitor (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200911), or more than one ART class (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20093). The median (95% confidence interval [CI]) percentage change in BMD at the lumbar spine from 0 to 48 weeks in the immediate switch group was 1.97% (\u22121.15 to 5.49) compared with a median (95% CI) decrease of 2.32% (\u22125.11 to 0.19) in the delayed arm. The median (95% CI) percentage change in BMD from 0 to 96 weeks was 2.33% (0\u20134.51) in the immediate arm compared with 0.70% (\u22123.19 to 2.47) in the delayed arm. We demonstrated a trend to increased BMD at the lumbar spine after a switch from TDF to TAF in peri- and early postmenopausal women living with HIV.\n                  <\/jats:p>\n                  <jats:p>\n                    Clinical\n                    <jats:uri xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/Trials.gov:\">Trials.gov:<\/jats:uri>\n                    NCT02815566.\n                  <\/jats:p>","DOI":"10.1089\/aid.2022.0106","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T06:47:00Z","timestamp":1670914020000},"page":"204-210","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["BEING: Bone Health in Aging Women with HIV: Impact of Switching Antiretroviral Therapy on Bone Mineral Density During the Perimenopausal Period"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3959-5692","authenticated-orcid":false,"given":"Sharon","family":"Walmsley","sequence":"first","affiliation":[{"name":"University Health Network, Toronto, Canada."},{"name":"Faculty of Medicine, University of Toronto, Toronto, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemarie","family":"Clarke","sequence":"additional","affiliation":[{"name":"University Health Network, Toronto, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry","family":"Lee","sequence":"additional","affiliation":[{"name":"Canadian HIV Trials Network, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Singer","sequence":"additional","affiliation":[{"name":"Canadian HIV Trials Network, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela M.","family":"Cheung","sequence":"additional","affiliation":[{"name":"University Health Network, Toronto, Canada."},{"name":"Faculty of Medicine, University of Toronto, Toronto, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Smaill","sequence":"additional","affiliation":[{"name":"Department of Lab Sciences, Mc Master University, Hamilton, Canada."},{"name":"Hamilton Health Sciences, Hamilton, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"De Pokomandy","sequence":"additional","affiliation":[{"name":"Department of Medicine, McGill University Health Center, Montreal, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Trottier","sequence":"additional","affiliation":[{"name":"Department of Medicine, CHU de Qu\u00e9bec-Universit\u00e9 Laval, Quebec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Messina","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, IRCCS Ospedale San Raffaele, Milano, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Guaraldi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Modena and Reggio Emilia, Modena, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001374"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00063-8"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir627"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.11599\/germs.2016.1092"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0428-7"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/coh.0000000000000269"},{"key":"e_1_3_4_8_2","unstructured":"World Health Organization. Expert Insight on Osteoporosis. 2016. Available from: www.4bonehealth.org\/education\/world-health-organization-criteria-diagnosis-osteoporosis\/ [Last accessed: December 1 2022]."},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32801022eb"},{"key":"e_1_3_4_10_2","first-page":"118","article-title":"Immune dysfunction, inflammation, and accelerated aging in patients on antiretroviral therapy","volume":"17","author":"Deeks SG","year":"2009","unstructured":"Deeks SG. Immune dysfunction, inflammation, and accelerated aging in patients on antiretroviral therapy. Top HIV Med, 2009; 17:118\u2013123.","journal-title":"Top HIV Med"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e32835c7134"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0000000000000918"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-016-0749-8"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000320"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/656417"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193679"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/644785"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw204"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328361d241"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2009.00716.x"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2055-6640(20)30248-X"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(15)00348-5"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/qai.0000000000000908"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ010"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070050"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650090802"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.88a.20199"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-10-55"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab341"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2010.01.2102"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S194543"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz038"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afx013"},{"key":"e_1_3_4_34_2","unstructured":"World Health Organization. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: report of a WHO study group [meeting held in Rome from 22 to 25 June 1992]. 1994. WHO technical report series; 843. 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