{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:46:43Z","timestamp":1792057603686,"version":"4.4.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>\n                    Recent studies suggest that the introduction of antiretroviral agents such as integrase strand transfer inhibitors (INSTI) may lead to weight gain in people living with HIV (PLHIV). In this retrospective observational study, we report the weight changes observed in virologically suppressed HIV patients after 12 months of switching to bictegravir\/emtricitabine\/tenofovir alafenamide (BIC\/F\/TAF) due to a national change in public policy in Mexico. Patients on prior regimens based on TDF\/FTC or ABC\/3TC plus non-nucleoside retrotranscriptase inhibitor, INSTI, or protease inhibitor were included. In the 399 patients analyzed, a significant weight increase was found, as well as an increase in body mass index (BMI), total cholesterol, low-density lipoprotein cholesterol (LDL-C), glucose, creatinine, and CD4\n                    <jats:sup>+<\/jats:sup>\n                    cells after 12 months of switching treatment (all\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009\u2264\u2009.001). Mean weight gain was 1.63\u2009kg [confidence interval (95% CI): 1.14\u20132.11], whereas the average percentage of weight gained was 2.5% (95% CI: 1.83\u20133.17). After considering the confounding effect of baseline weight status, the change in weight and BMI did not present significant differences between any of the prior treatment schemes. In conclusion, PLHIV switching to BIC\/F\/TAF therapy experienced weight gain after the first year of switching treatment. Although this weight gain could be due to the switch in treatment regimen, it cannot be excluded that it was caused by other factors since no comparable control group could be used for comparison.\n                  <\/jats:p>","DOI":"10.1089\/aid.2022.0130","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T11:28:24Z","timestamp":1681817304000},"page":"511-517","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Weight Gain After 12 Months of Switching to Bictegravir\/Emtricitabine\/Tenofovir Alafenamide in Virologically Suppressed HIV Patients"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3839-1567","authenticated-orcid":false,"given":"Edgar","family":"P\u00e9rez-Barrag\u00e1n","sequence":"first","affiliation":[{"name":"Servicio de Infectolog\u00eda, Hospital General de Zona N\u00b0 48, Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3777-2947","authenticated-orcid":false,"given":"M\u00f3nica Fernanda","family":"Guevara-Maldonado","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital General de Zona N\u00b0 48, Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0718-467X","authenticated-orcid":false,"given":"Javier","family":"Mancilla-Galindo","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Posgrado, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3875-0945","authenticated-orcid":false,"given":"Ashuin","family":"Kammar-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Investigaci\u00f3n, Instituto Nacional de Geriatr\u00eda, Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1714-9560","authenticated-orcid":false,"given":"Alejandro","family":"Ortiz-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1329-7811","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Mata-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Servicio de Infectolog\u00eda, Hospital de Infectolog\u00eda, Centro M\u00e9dico Nacional La Raza, Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1222-1930","authenticated-orcid":false,"given":"Samantha","family":"P\u00e9rez-Cavazos","sequence":"additional","affiliation":[{"name":"Departamento de Epidemiolog\u00eda Hospitalaria\/Servicio de Infectolog\u00eda, Hospital Christus Muguerza Betania, Puebla, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"World Health Organization. Obesity and Overweight. [Internet]. World Health Organization. [Updated: June 2021; Reviewed: May 2023]. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S67400"},{"key":"e_1_3_5_4_2","unstructured":"Pineda EB Lazcano-Ponce E Mart\u00ednez-Barnetche J et al. National Health and Nutrition Survey 2020 on Covid-19. National Results. National Institute of Public Health. [Updated: 2021; Reviewed: May 2023]. Available from: https:\/\/www.insp.mx\/avisos\/reporte-completo-resultados-nacionales"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-020-00483-5"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131353"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2021.10.017"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.1044436"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz414"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz999"},{"key":"e_1_3_5_11_2","unstructured":"Official Journal of the Federation. Antiretroviral Management Guide of People with HIV [Internet]. Secretary of Governance. [Updated: July 2019; Reviewed: May 2023]. Available from: https:\/\/www.dof.gob.mx\/nota_detalle.php?codigo=5565176&fecha=08\/07\/2019#gsc.tab=0"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32299-7"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32340-1"},{"key":"e_1_3_5_14_2","unstructured":"Arribas J Orkin C Maggiolo F et al. Long-term analysis of B\/F\/TAF in treatment-na\u00efve adults living with HIV through four years of follow-up. 11th IAS Conference on HIV Science abstract PEB151 2021."},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac036"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa988"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25702"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofu040"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-021-00419-5"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2015.0147"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07091-1"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0181-1"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz853"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(20)30241-1"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002496"},{"key":"e_1_3_5_26_2","unstructured":"Institute for Health Metrics and Evaluation (IHME). GBD Compare. [Internet] Seattle WA: IHME University of Washington [Updated: 2021; Reviewed: May 2023]. Available from: https:\/\/vizhub.healthdata.org\/gbd-compare"},{"key":"e_1_3_5_27_2","unstructured":"Undersecretary of Prevention and Health Promotion. HIV Epidemiological Surveillance System. Report Historic World HIV Day 2022 [Internet]. Ministry of Health Mexico. [Updated: 2022; Reviewed: May 2023]. Available from: https:\/\/www.gob.mx\/cms\/uploads\/attachment\/file\/782936\/InformeHistorico_VIH_DVEET_DIAMUNDIALVIH2022.pdf"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.3822"}],"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/aid.2022.0130","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2022.0130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2022.0130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:16:37Z","timestamp":1777367797000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/aid.2022.0130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1089\/aid.2022.0130"],"URL":"https:\/\/doi.org\/10.1089\/aid.2022.0130","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]}}}