{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:02:07Z","timestamp":1787785327057,"version":"build-2784847793"},"reference-count":11,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>\n                    In this study, a total of 462 samples of whole blood were collected from 36 patients enrolled. During the entire course of antiretroviral therapy (ART) from 2003 to 2019, both the CD4 cell count and viral load (VL) of study patients were examined annually, and an HIV-1 genotypic drug resistance (DR) assay was carried out using an in-house method when the HIV-1 VL was &gt;1,000 copies\/mL. The results indicated that 13 (36.1%) experienced treatment failure and 23 (63.9%) experienced treatment success among 36 patients. The proportion of patients with effective treatment after the adjustment of ART regimens was significantly higher than before adjustment (\u03c7\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200933.796,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u2009.001). Furthermore, the frequencies of HIV-1 DR mutations before adjustment were higher than those after adjustment (\n                    <jats:italic toggle=\"yes\">t<\/jats:italic>\n                    \u2009=\u20093.345,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.002). In particular, among 23 patients with effective treatment after adjustment, the means\u2009\u00b1\u2009standard deviations of the VLs and CD4 cell counts before adjustment were 3.85\u2009\u00b1\u20090.65 log RNA copies\/mL and 226.83\u2009\u00b1\u2009106.06 cells\/mm\n                    <jats:sup>3<\/jats:sup>\n                    , respectively, compared with 2.19\u2009\u00b1\u20090.58 log RNA copies\/mL and 367.68\u2009\u00b1\u2009174.62 cells\/mm\n                    <jats:sup>3<\/jats:sup>\n                    , respectively, after adjustment. Obviously, there were statistically significant differences in the changes in VL (\n                    <jats:italic toggle=\"yes\">t<\/jats:italic>\n                    \u2009=\u20098.728,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u2009.001) and CD4 cell count (\n                    <jats:italic toggle=\"yes\">t<\/jats:italic>\n                    \u2009=\u2009\u22124.476,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u2009.001) before and after adjustment. Therefore, patients who received updated ART regimens containing LPV\/r and TDF after adjustment achieved better therapeutic effects compared with patients who received initial ART regimens harboring D4T\/AZT or NVP. This suggests that future research is needed to initiate the surveillance of DR, VLs, and CD4 cell counts immediately after HIV diagnosis, and dynamic changes in these indicators so as to optimize ART effects.\n                  <\/jats:p>","DOI":"10.1089\/aid.2023.0006","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T08:20:14Z","timestamp":1687162814000},"page":"558-566","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Changes of Viral Load, Drug Resistance, and CD4 Cell Count in HIV-1\u2013Infected Patients Receiving Antiretroviral Therapy in Hebei Province, China, 2003\u20132019"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4613-2028","authenticated-orcid":false,"given":"Xinli","family":"Lu","sequence":"first","affiliation":[{"name":"Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Xu","sequence":"additional","affiliation":[{"name":"Graduate College of Hebei Medical University, Shijiazhuang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"An","sequence":"additional","affiliation":[{"name":"Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"e_1_3_7_2_2","unstructured":"UNAIDS. World AIDS Day Report; 2020. Available from: https:\/\/mp.weixin.qq.com\/s\/J5YK4 mku7VDSOx0wtK6tAQ [Last accessed: July6 2020]."},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1010539516650721"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871526517666170505122800"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0254-6450.2015.05.01l"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2016.03.004"},{"key":"e_1_3_7_7_2","unstructured":"Book Writing Group. Manual of the National Free Antiretroviral Treatment 1st 2nd 3rd and 4th ed. People's Medical Publishing House: Beijing; 2005\u20132016."},{"key":"e_1_3_7_8_2","unstructured":"Wang TX. A Summary of HIV\/AIDS Epidemic Situation Across the Country in 2020. Available from: https:\/\/xw.qq.com\/amphtml\/20201207A0B1EE00.2020-12-07 [Last accessed: December7 2020]."},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12981-017-0133-3"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-025666"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1797280"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016886"}],"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/aid.2023.0006","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2023.0006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2023.0006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:16:38Z","timestamp":1777367798000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/aid.2023.0006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1089\/aid.2023.0006"],"URL":"https:\/\/doi.org\/10.1089\/aid.2023.0006","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]}}}