{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:18:49Z","timestamp":1781522329578,"version":"3.54.1"},"reference-count":51,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>\n                    We explored factors associated with weight gain among people with HIV (PWH) on antiretroviral therapy (ART) at The Ohio State University Wexner Medical Center (OSUWMC). This was a retrospective cohort study of adult PWH on ART for \u22653 months. Patients with CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell count &lt;200 cells\/mm\n                    <jats:sup>3<\/jats:sup>\n                    , viral load &gt;200 copies\/mL, history of malignancy, or pregnancy were excluded. Eight hundred seventy patients met criteria. The primary outcome was percent weight change over the follow-up period (\u0394\u2009=\u2009relative effects). The secondary outcome was the odds of \u22655 kg weight gain over the study period. The effects of concurrent medications, medical comorbidities, ART combinations, and lifestyle behaviors on these outcomes were modeled using mixed effects regression analyses. Over a mean follow-up of 1.86 years, the study population gained a mean percent weight of 2.12%\u2009\u00b1\u20090.21% (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u2009.001) with the odds of \u22655\u2009kg weight gain of 0.293 (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u2009.001). Males gained an average of 1.88%\u2009\u00b1\u20090.22% over follow up, while females gained an average of 3.37%\u2009\u00b1\u20090.51% over follow up (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.008 for the difference). In regression models, combination therapy with tenofovir alafenamide (TAF) and integrase strand transfer inhibitor (INSTI) containing regimens was associated with an increase in weight over the study period (\u0394\u2009=\u20092.14%\u2009\u00b1\u20090.45%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u2009.001 and \u0394\u2009=\u20091.09%\u2009\u00b1\u20090.39%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.005, respectively). Increasing age was significantly associated with a decrease in percent weight change over the study period (\u0394\u2009=\u2009\u22120.68%\u2009\u00b1\u20090.18% per year,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u2009.001). Self-reported improvement in diet was associated with a decrease in weight change (\u0394\u2009=\u2009\u22121.99%\u2009\u00b1\u20090.47%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009\u2264\u2009.001) and reduced odds of \u22655\u2009kg weight gain (odds ratio\u2009=\u20090.70, 95% confidence interval\u2009=\u20090.50\u20130.97,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.03). Factors associated with weight gain include therapy with TAF and INSTI. Diet may play an influential role in attenuating weight gain in PWH.\n                  <\/jats:p>","DOI":"10.1089\/aid.2023.0008","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T13:01:10Z","timestamp":1685970070000},"page":"652-661","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Weight Gain in People with HIV: The Role of Demographics, Antiretroviral Therapy, and Lifestyle Factors on Weight"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4790-9062","authenticated-orcid":false,"given":"Yesha S.","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali D.","family":"Doshi","sequence":"additional","affiliation":[{"name":"College of Medicine, The Ohio State University, Columbus, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Levesque","sequence":"additional","affiliation":[{"name":"College of Medicine, The Ohio State University, Columbus, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelsie","family":"Lindor","sequence":"additional","affiliation":[{"name":"College of Medicine, The Ohio State University, Columbus, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Moranville","sequence":"additional","affiliation":[{"name":"College of Medicine, The Ohio State University, Columbus, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila C.","family":"Okere","sequence":"additional","affiliation":[{"name":"College of Medicine, The Ohio State University, Columbus, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle B.","family":"Robinson","sequence":"additional","affiliation":[{"name":"College of Medicine, The Ohio State University, Columbus, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Taylor","sequence":"additional","affiliation":[{"name":"College of Medicine, The Ohio State University, Columbus, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Lustberg","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA."},{"name":"Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos D.","family":"Malvestutto","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ192"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32832913ee"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181b32baf"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833b784a"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000010"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2015.0147"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2012.0234"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010106"},{"issue":"5","key":"e_1_3_5_10_2","first-page":"557","article-title":"A tale of 2 epidemics: The intersection between obesity and HIV infection in Philadelphia","volume":"39","author":"Amorosa V","year":"2005","unstructured":"Amorosa V, , Synnestvedt M, , Gross R, et al. 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