{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:45:48Z","timestamp":1777380348319,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n                    Hematological malignant tumors (HMTs) are serious diseases that threaten human health and life with high mortality. Therefore, it is necessary to develop novel strategies for diagnosis and treatment. Human endogenous retroviruses (HERVs) have recently attracted increasing attention as potential targets for cancer diagnosis and therapy. In this study, we explored the association between HERV-K expression levels and HMTs development. Clinical data and peripheral blood samples were collected from 236 leukemia, 384 lymphoma patients, and 69 healthy controls. Quantitative polymerase chain reaction was used to detect the expression of HERV-K\n                    <jats:italic toggle=\"yes\">gag<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">pol<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">env<\/jats:italic>\n                    genes in peripheral blood mononuclear cells or different cell subpopulations. Differently expressed HERV-K genes were further tested by using deep sequencing method, and further analyzed with gene ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. B cell- and T cell-related cytokines in patients were also detected by enzyme-linked immunosorbent assay (ELISA). The results showed that the expression levels of the HERV-K\n                    <jats:italic toggle=\"yes\">gag<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">pol<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">env<\/jats:italic>\n                    genes in patients were significantly higher than in healthy controls. There was a correlation between the expression level of HERV-K and the clinicopathological parameters of leukemia patients. HERV-K expression was increased in the B lymphocytes of leukemia and lymphoma patients, but not in the T cells or neutrophils. The GO and KEGG analyses showed that abnormal expression of the HERV-K locus in patients affected immune regulation. The analysis of cytokines proved that the B cell-related cytokines, including interleukin (IL)-1\u03b2, IL-2, IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-\u03b1, and interferon-gamma, were significantly decreased in patients, while the T cell-related cytokines, including IL-3, IL-12, and TNF-\u03b2, were not significantly changed. In conclusion, HERV-K genes might participate in the occurrence and development of leukemia and lymphoma, and might be biomarkers for the detection or evaluation of leukemia and lymphoma.\n                  <\/jats:p>","DOI":"10.1089\/aid.2023.0037","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T03:57:41Z","timestamp":1701057461000},"page":"268-279","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Higher Expression of Human Endogenous Retrovirus-K was Observed in Peripheral B Lymphocytes of Leukemia and Lymphoma Patients"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7907-8550","authenticated-orcid":false,"given":"Tianfu","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity, Department of AIDS Research, Beijing Institute of Microbiology and Epidemiology, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Qian","sequence":"additional","affiliation":[{"name":"Nankai University School of Medicine, Tianjin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwan","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity, Department of AIDS Research, Beijing Institute of Microbiology and Epidemiology, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjian","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity, Department of AIDS Research, Beijing Institute of Microbiology and Epidemiology, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity, Department of AIDS Research, Beijing Institute of 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