{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:43:08Z","timestamp":1777380188543,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>\n                    CRF01_AE and CRF07_BC are the two predominant HIV-1 subtypes currently circulating in China. We identified here a novel CCR5-tropic HIV-1 second-generation recombinant form virus found in two individuals, (GX19017 and GX19032), which were isolated from two HIV-1-positive people in Guangxi, southwest China. Phylogenic analyses indicated that these two sequences were all composed of two well-established circulating recombinant forms (CRFs) CRF07_BC and CRF01_AE, with four recombinant breakpoints observed in the\n                    <jats:italic toggle=\"yes\">pol<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">vpu<\/jats:italic>\n                    \/\n                    <jats:italic toggle=\"yes\">env<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">env<\/jats:italic>\n                    gene regions, respectively. The recombinant CRF01_AE region was clustered with the previously described CRF01_AE subcluster 2 lineage, which was characterized by the susceptibility to phenotypic transfer. The genome structure is significantly different from other previously reported CRFs and unique recombination forms. The emergence of a series of novel recombinant strains is indicative of the burgeoning complexity of the HIV-1 epidemic among the sexually transmitted population. Meanwhile, it may furnish significant insights into the dynamics and intricacy of the HIV-1 epidemic in China.\n                  <\/jats:p>","DOI":"10.1089\/aid.2023.0043","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T08:20:32Z","timestamp":1687162832000},"page":"567-574","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Near Full-Length Genomic Characterization of Two Novel HIV Type 1 Second-Generation Recombinant Forms (CRF01_AE\/CRF07_BC) from Guangxi, China"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6854-5571","authenticated-orcid":false,"given":"Meiliang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanhuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and Prevention, Nanning, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and Prevention, Nanning, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1209-0778","authenticated-orcid":false,"given":"Wenlong","family":"Cai","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and Prevention, Nanning, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haomin","family":"Xie","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and Prevention, Nanning, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghua","family":"Lan","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and Prevention, Nanning, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708559104"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(18)30647-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006841"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07390"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03470-x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03426-1"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg3055"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abk1688"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047289"},{"issue":"5","key":"e_1_3_3_11_2","first-page":"290","article-title":"Analysis of data AIDS sentinel surveillance from 1996 to 2003 in Guangxi province","volume":"12","author":"Zhu Q","year":"2006","unstructured":"Zhu Q, , Liu W, , Chen J, et al. 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