{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:45:57Z","timestamp":1777380357993,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>Previously, an increase in clinical effectiveness of the antituberculosis treatment (ATT) and antiretroviral therapy (ART) in case of additional immunoglobulin G (IgG) administration in patients with multidrug-resistant tuberculosis (MDR-TB)\/HIV coinfection was reported. The aim of this study was to investigate the impact of IgG administration in addition to the standard second-line ATT and ART on the humoral immunity status in patients with MDR-TB\/HIV coinfection immune deficiency. The study involved 52 patients living with HIV with MDR-TB coinfection and CD4+ lymphocyte cell count below 50 cells\/\u03bcCL. Patients in the control group and intervention group received the second-line ATT and ART; in addition, patients in the intervention group received IgG intravenously. The humoral immunity status was evaluated by measurement of IgA, IgE, IgG, and IgM in plasma. The standard ATT and ART resulted in a two-step change in humoral immunity: IgM, IgG, IgA, and IgE levels gradually increased to a maximal level at the 5-month mark and started to gradually decrease after the 8-month mark. Addition of IgG to the standard therapy resulted in a steeper decrease in the immunoglobulin level in serum, especially IgG, compared with standard therapy alone, allowing for an earlier initiation of ART in patients in the intervention group.<\/jats:p>","DOI":"10.1089\/aid.2023.0074","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T03:30:16Z","timestamp":1704166216000},"page":"246-252","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of Immunoglobulin G on the Humoral Immunity in Patients with Tuberculosis\/HIV Coinfection"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9697-1615","authenticated-orcid":false,"given":"Nina A.","family":"Matsegora","sequence":"first","affiliation":[{"name":"Department of Phthisiopulmonology and Odesa National Medical University, Odesa, Ukraine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonina V.","family":"Kaprosh","sequence":"additional","affiliation":[{"name":"Department of Phthisiopulmonology and Odesa National Medical University, Odesa, Ukraine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetyana I.","family":"Vasylyeva","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petro B.","family":"Antonenko","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacognosy, Odesa National Medical University, Odesa, Ukraine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kateryna","family":"Antonenko","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacognosy, Odesa National Medical University, Odesa, Ukraine."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"e_1_3_5_2_2","volume-title":"Global Tuberculosis Control Report","author":"WHO","unstructured":"WHO. Global Tuberculosis Control Report. WHO Report: Switzerland, Geneva; 2019."},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.15407\/microbiolj78.02.103"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1125"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001169"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003270"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217742"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2019.1621148"},{"key":"e_1_3_5_9_2","first-page":"559","article-title":"Intravenous immunoglobulin in septic shock: Review of the mechanisms of action and meta-analysis of the clinical effectiveness","volume":"82","author":"Busani S","year":"2016","unstructured":"Busani S, , Damiani E, , Cavazzuti I, et al. Intravenous immunoglobulin in septic shock: Review of the mechanisms of action and meta-analysis of the clinical effectiveness. Minerva Anestesiol, 2016; 82:559\u2013572.","journal-title":"Minerva Anestesiol"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijmy.ijmy_122_19"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijmy.ijmy_21_21"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.10.4.702-709.2003"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12060818"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05550-11"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02846"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106631"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-6111-1_12"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.907930"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0276610"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ614"},{"issue":"3","key":"e_1_3_5_21_2","first-page":"201","article-title":"Association between tuberculosis and atopy: Role of the CD14\u2013159C\/T polymorphism","volume":"22","author":"Ba\u00e7\u00e7io\u011flu Kavut A","year":"2012","unstructured":"Ba\u00e7\u00e7io\u011flu Kavut A, , Kalpaklio\u011flu F, , Birben E, et al. Association between tuberculosis and atopy: Role of the CD14\u2013159C\/T polymorphism. J Investig Allergol Clin Immunol, 2012; 22(3):201\u2013207.","journal-title":"J Investig Allergol Clin Immunol"}],"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/aid.2023.0074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2023.0074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2023.0074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:17:06Z","timestamp":1777367826000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/aid.2023.0074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1089\/aid.2023.0074"],"URL":"https:\/\/doi.org\/10.1089\/aid.2023.0074","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]}}}