{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:02:06Z","timestamp":1784628126308,"version":"3.55.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:p>Various modalities are being explored in HIV cure-related research, but little is documented on their acceptability in Africa, where HIV is most prevalent. To address this, we conducted a cross-sectional study in Soweto, South Africa, assessing stated acceptability of five potential HIV cure-related research modalities and identifying associated factors. Between May and August 2024, we sampled 100 adults living with HIV who provided informed consent. Participants completed questionnaires of socio-demographics and the Theoretical Framework of Acceptability scale measuring general acceptability and seven constructs (affective attitude, burden, ethicality, perceived effectiveness, intervention coherence, self-efficacy, opportunity costs). We summarized data using descriptive statistics. We assessed factors associated with acceptability using univariate and multivariate logistic regression. We found that of 100 participants (44% female, median age 39 years), 66% were willing to accept an intervention that would allow lifelong remission (antiretroviral treatment-free control), 88% were willing if the intervention guaranteed remission for everyone treated, and 87% were willing if the intervention had minimal side effects. Total mean acceptability scores of hypothetical HIV cure-related research modalities were oral or injectable chemotherapeutics (3.8\/5), intravenous or injectable antibodies (3.7\/5), radiotherapy (3.3\/5), transplantation (3.1\/5), gene therapy (2.9\/5), and across all modalities (3.4\/5). Participants rated antibodies and chemotherapeutics with tied top scores for affective attitude (3.8\/5) and self-efficacy (4.0\/5); chemotherapeutics with top scores for perceived effectiveness (4.0\/5), intervention coherence (4.1\/5) and having least burden (3.2\/5) and opportunity costs (3.3\/5); and antibodies with the top score for ethicality (4.2\/5). Acceptability was associated with non-binary gender and willingness to take an intervention achieving 2 years remission. In conclusion, people living with HIV have moderately high acceptability for oral or injectable chemotherapeutics and intravenous or injectable antibodies but would need more information about gene therapy, transplantation, and radiotherapy. Antibodies aligned highest with personal values, suggesting support for antibody research and applications.<\/jats:p>","DOI":"10.1089\/aid.2025.0002","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T10:00:37Z","timestamp":1750759237000},"page":"517-525","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Acceptability of Hypothetical HIV Cure-Related Research Modalities: A Cross-Sectional Study of People Living with HIV in Soweto, South Africa"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5231-9951","authenticated-orcid":false,"given":"Fatima","family":"Laher","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mbalenhle","family":"Sibiya","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naledi","family":"Mahlangu","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennedy","family":"Otwombe","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa."},{"name":"Faculty of Health Sciences, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.12.011"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2055-6640(20)30030-3"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.636642"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1478703"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2018.2481"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2024.07.012"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-017-2031-8"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12981-020-00321-z"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/25787489.2025.2455917"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2019.0021"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12910-021-00651-1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1711460"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17091413"},{"key":"e_1_3_3_15_2","unstructured":"Statistics South Africa. Statistical Release Mid-year population estimates 2017 [Internet]. Available from: http:\/\/www.statssa.gov.za\/publications\/P0302\/P03022017.pdf [Last accessed: Decemebr1 2024]."},{"key":"e_1_3_3_16_2","unstructured":"Statistics South Africa. Statistics South Africa Census 2022 [Internet]. Available from: http:\/\/census.statssa.gov.za\/ [Last accessed: Decemebr1 2024]."},{"key":"e_1_3_3_17_2","unstructured":"Human Sciences Research Council. Fifth South African National HIV Prevalence Incidence Behaviour and Communication Survey (SABSSM V) 2024. Available from: https:\/\/hsrc.ac.za\/uploads\/pageContent\/9234\/SABSSMV_Impact_Assessment_Summary_ZA_ADS_cleared_PDFA4.pdf [Last accessed: Decemebr1 2024]."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2019.197"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000083910"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-022-07577-3"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25889"},{"issue":"47","key":"e_1_3_3_22_2","first-page":"945","article-title":"Differences between HIV-Infected men and women in antiretroviral therapy outcomes\u2014six African countries, 2004\u20132012","volume":"62","author":"Etti\u00e8gne-Traor\u00e9 V","year":"2013","unstructured":"Etti\u00e8gne-Traor\u00e9 V, , Tuho MZ, , Mohamed F, et al. Differences between HIV-Infected men and women in antiretroviral therapy outcomes\u2014six African countries, 2004\u20132012. MMWR Morb Mortal Wkly Rep, 2013; 62(47):945.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/jan.15240"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.4102\/sajhivmed.v26i1.1644"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2055-6640(20)30295-8"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jve.2020.100027"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcsop.2023.100378"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/26330040211047244"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.28352"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-024-00712-1"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-586-6_2"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/21501327211019282"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40290-023-00473-z"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12981-025-00734-8"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0003418"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01555-w"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2014.02.021"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170112"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24878"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841869709001360"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.5210\/ojphi.v4i3.4321"},{"key":"e_1_3_3_42_2","unstructured":"UNAIDS. Human Rights Fact Sheet Series. 2021. Available from: https:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/04-hiv-human-rights-factsheet-transgender-gender-diverse_en.pdf [Last accessed: April15 2025]."}],"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/aid.2025.0002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2025.0002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/aid.2025.0002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:09:35Z","timestamp":1784624975000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/aid.2025.0002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,12,1]]}},"alternative-id":["10.1089\/aid.2025.0002"],"URL":"https:\/\/doi.org\/10.1089\/aid.2025.0002","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,24]]}}}