{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:01:59Z","timestamp":1784628119149,"version":"3.55.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:p>\n                    Estimating the prevalence and characterizing the HIV-1 transmitted drug resistance (TDR) are crucial for the prevention and control of HIV\/AIDS. However, there are limited data currently on TDR among men who have sex with men (MSM) in Zhenjiang, Jiangsu, a high-risk population for drug resistance. We conducted a retrospective analysis among the newly diagnosed and antiretroviral therapy (ART)-naive HIV-1-infected MSM in Zhenjiang, 2012\u20132018. We analyzed the HIV-1 subtypes, TDR prevalence, TDR-associated mutations, and predicted drug sensitivity. Among these 192 participants, CRF01_AE (50.0%) and CRF07_BC (34.9%) were the predominant HIV-1 strains, with an increasing diversity of circulating subtypes (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; .05). A total of nine patients infected with CRF01_AE exhibited one or more TDR mutations, including 3.6% for Protease Inhibitor (PI)-related mutations, 1.0% for NRTI-related mutations and 1.0% for NNRTI-related mutations. The most common mutation was M46L\/I for PIs. Notably, TDR prevalence showed an upward trend from 2012 to 2018, with an average of 4.7%. The gradually diversified subtypes, the increased TDR prevalence, and the potential risk of transmitting drug-resistant strains to the general population highlight the necessity of TDR monitoring in MSM. This will be beneficial for the prevention and control of HIV\/AIDS in Zhenjiang.\n                  <\/jats:p>","DOI":"10.1089\/aid.2025.0032","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T15:04:30Z","timestamp":1751036670000},"page":"534-540","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The HIV-1 Transmitted Drug Resistance in Newly Confirmed and ART-Na\u00efve HIV-1-Infected MSM in Zhenjiang City, Jiangsu, China"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3068-4138","authenticated-orcid":false,"given":"Li","family":"Shen","sequence":"first","affiliation":[{"name":"Zhenjiang Center of Diseases Control and Prevention, Zhenjiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhenjiang Center of Diseases Control and Prevention, Zhenjiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhenjiang Center of Diseases Control and Prevention, Zhenjiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Ye","sequence":"additional","affiliation":[{"name":"Zhenjiang Center of Diseases Control and Prevention, Zhenjiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Zhenjiang Center of Diseases Control and Prevention, Zhenjiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhenjiang Center of Diseases Control and Prevention, Zhenjiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhenjiang Center of Diseases Control and Prevention, Zhenjiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"issue":"1","key":"e_1_3_3_2_2","first-page":"5","article-title":"First case of AIDS diagnosed in China","volume":"68","author":"Zheng YY","year":"1988","unstructured":"Zheng YY. First case of AIDS diagnosed in China. Zhonghua Yi Xue Za Zhi, 1988; 68(1):5\u20136.","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290354"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.13419\/j.cnki.aids.2012.01.005"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0366-6999.2012.11.003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105243"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2009.07.009"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328013caff"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283388742"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70032-9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2016.08.031"},{"key":"e_1_3_3_12_2","unstructured":"Zhengjiang Municipal Health Commision. 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