{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:37:16Z","timestamp":1791895036336,"version":"4.3.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Appl Biosaf."],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Lack of evidence-based information regarding potential biological risks can result in inappropriate or excessive biosafety and biosecurity risk-reduction strategies. This can cause unnecessary damage and loss to the physical facilities, physical and psychological well-being of laboratory staff, and community trust. A technical working group from the World Organization for Animal Health (WOAH, formerly OIE), World Health Organization (WHO), and Chatham House collaborated on the Biosafety Research Roadmap (BRM) project. The goal of the BRM is the sustainable implementation of evidence-based biorisk management of laboratory activities, particularly in low-resource settings, and the identification of gaps in the current biosafety and biosecurity knowledge base.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A literature search was conducted for the basis of laboratory design and practices for four selected high-priority subgroups of pathogenic agents. Potential gaps in biosafety were focused on five main sections, including the route of inoculation\/modes of transmission, infectious dose, laboratory-acquired infections, containment releases, and disinfection and decontamination strategies. Categories representing miscellaneous, respiratory, bioterrorism\/zoonotic, and viral hemorrhagic fever pathogens were created within each group were selected for review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Information sheets on the pathogens were developed. Critical gaps in the evidence base for safe sustainable biorisk management were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The gap analysis identified areas of applied biosafety research required to support the safety, and the sustainability, of global research programs. Improving the data available for biorisk management decisions for research with high-priority pathogens will contribute significantly to the improvement and development of appropriate and necessary biosafety, biocontainment and biosecurity strategies for each agent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/apb.2022.0040","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T11:48:42Z","timestamp":1684151322000},"page":"64-71","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["The Biosafety Research Road Map: The Search for Evidence to Support Practices in Human and Veterinary Laboratories"],"prefix":"10.1177","volume":"28","author":[{"given":"Stuart D.","family":"Blacksell","sequence":"first","affiliation":[{"name":"Mahidol-Oxford Tropical Research Medicine Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Nuffield Department of Medicine Research Building, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Dhawan","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Research Medicine Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Kusumoto","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Research Medicine Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim Khanh","family":"Le","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Research Medicine Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5519-5966","authenticated-orcid":false,"given":"Kathrin","family":"Summermatter","sequence":"additional","affiliation":[{"name":"Institute for Infectious Diseases, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"O'Keefe","sequence":"additional","affiliation":[{"name":"Ministry for Primary Industries, Wellington, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kozlovac","sequence":"additional","affiliation":[{"name":"United States Department of Agriculture, Agricultural Research Service, Beltsville, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salama Suhail","family":"Almuhairi","sequence":"additional","affiliation":[{"name":"Abu Dhabi Agriculture and Food Safety Authority, Abu Dhabi, United Arab Emirates."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indrawati","family":"Sendow","sequence":"additional","affiliation":[{"name":"Research Center for Veterinary Science, National Research and Innovation Agency, Indonesia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Scheel","sequence":"additional","affiliation":[{"name":"WHO Collaborating Center for Biosafety and Biosecurity, Office of the Associate Director for Laboratory Science, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4651-4424","authenticated-orcid":false,"given":"Anthony","family":"Ahumibe","sequence":"additional","affiliation":[{"name":"Nigeria Centre for Disease Control and Prevention, Abuja, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zibusiso M.","family":"Masuku","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan M.","family":"Bennett","sequence":"additional","affiliation":[{"name":"UK Health Security Agency, Porton Down, Salisbury, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunobu","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Epidemic and Pandemic Preparedness and Prevention, World Health Organization (WHO), Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Harper","sequence":"additional","affiliation":[{"name":"The Royal Institute of International Affairs, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Hamilton","sequence":"additional","affiliation":[{"name":"World Organisation for Animal Health (OIE), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"NSF International Standard\/American National Standard. NSF\/ANSI 49-2019 Biosafety Cabinetry: Design Construction Performance and Field Certification. NSF: Ann Arbor; 2020."},{"key":"e_1_3_4_3_2","unstructured":"Johnson B. Cost-effective Biosafety and Biosecurity: Success Models from Around the Globe. \u201cThe 2012 International Conference on Biocontainment Facilities\u201d May 14\u201315\u2014Gaylord National Resort National Harbor MD."},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/apb.20.0042"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2004.03.015"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1535676017713739"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa507"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.15761\/CMID.1000S1004"},{"key":"e_1_3_4_9_2","unstructured":"Public Health Agency of Canada. Government of Canada. Notification and Reporting Under the HPTA and HPTR. Available from: https:\/\/www.canada.ca\/en\/public-health\/services\/canadian-biosafety-standards-guidelines\/guidance\/notification-reporting-human-pathogens-toxins-act-regulations-overview.html [Last accessed: January 11 2023]."},{"key":"e_1_3_4_10_2","unstructured":"Health and Safety Executive. Government of the United Kingdom. Reporting Accidents Incidents and Diseases. Available from: https:\/\/www.hse.gov.uk\/toolbox\/managing\/reporting.htm [Last accessed: January 11 2023]."},{"key":"e_1_3_4_11_2","unstructured":"Federal Select Agent Program. US Centers for Disease Control and Prevention USDA Animal and Plant Health Inspection Service. Select Agents Regulations. Available from: https:\/\/www.selectagents.gov\/regulations\/index.htm [Last accessed: January 11 2023]."},{"key":"e_1_3_4_12_2","unstructured":"World Organization for Animal Health. Biosafety and Biosecurity: Standard for Managing Biological Risk in the Veterinary Laboratory and Animal Facilities. World Organization for Animal Health: Paris; 2021."},{"key":"e_1_3_4_13_2","unstructured":"World Health Organization. Laboratory Biosafety Manual Fourth Edition. World Health Organization: Geneva; 2020."}],"container-title":["Applied Biosafety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/apb.2022.0040","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/apb.2022.0040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/apb.2022.0040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:38:26Z","timestamp":1777376306000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/apb.2022.0040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,15]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6,1]]}},"alternative-id":["10.1089\/apb.2022.0040"],"URL":"https:\/\/doi.org\/10.1089\/apb.2022.0040","relation":{},"ISSN":["1535-6760","2470-1246"],"issn-type":[{"value":"1535-6760","type":"print"},{"value":"2470-1246","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,15]]}}}