{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:53:41Z","timestamp":1777550021599,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Patient Care and STDs"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:p>\n                    Second-generation antipsychotics (SGAs) are increasingly prescribed to treat psychiatric symptoms in pediatric patients infected with HIV. We examined the relationship between prescribed SGAs and physical growth in a cohort of youth with perinatally acquired HIV-1 infection. Pediatric AIDS Clinical Trials Group (PACTG), Protocol 219C (P219C), a multicenter, longitudinal observational study of children and adolescents perinatally exposed to HIV, was conducted from September 2000 until May 2007. The analysis included P219C participants who were perinatally HIV-infected, 3\u201318 years old, prescribed first SGA for at least 1 month, and had available baseline data prior to starting first SGA. Each participant prescribed an SGA was matched (based on gender, age, Tanner stage, baseline body mass index [BMI]\n                    <jats:italic toggle=\"yes\">z<\/jats:italic>\n                    score) with 1\u20133 controls without antipsychotic prescriptions. The main outcomes were short-term (approximately 6 months) and long-term (approximately 2 years) changes in BMI\n                    <jats:italic toggle=\"yes\">z<\/jats:italic>\n                    scores from baseline. There were 236 participants in the short-term and 198 in the long-term analysis. In linear regression models, youth with SGA prescriptions had increased BMI\n                    <jats:italic toggle=\"yes\">z<\/jats:italic>\n                    scores relative to youth without antipsychotic prescriptions, for all SGAs (short-term increase\u2009=\u20090.192,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.003; long-term increase\u2009=\u20090.350,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and for risperidone alone (short-term\u2009=\u20090.239, p\u2009=\u20090.002; long-term\u2009=\u20090.360,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.001). Participants receiving both protease inhibitors (PIs) and SGAs showed especially large increases. These findings suggest that growth should be carefully monitored in youth with perinatally acquired HIV who are prescribed SGAs. Future research should investigate the interaction between PIs and SGAs in children and adolescents with perinatally acquired HIV infection.\n                  <\/jats:p>","DOI":"10.1089\/apc.2009.0121","type":"journal-article","created":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T15:20:02Z","timestamp":1255533602000},"page":"939-947","source":"Crossref","is-referenced-by-count":5,"title":["The Use of Second-Generation Antipsychotics and the Changes in Physical Growth in Children and Adolescents with Perinatally Acquired HIV"],"prefix":"10.1177","volume":"23","author":[{"given":"Suad","family":"Kapetanovic","sequence":"first","affiliation":[{"name":"University of Southern California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Aaron","sequence":"additional","affiliation":[{"name":"Harvard School of Public Health Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Montepiedra","sequence":"additional","affiliation":[{"name":"Harvard School of Public Health Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Sirois","sequence":"additional","affiliation":[{"name":"Tulane University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Oleske","sequence":"additional","affiliation":[{"name":"UMDNJ\u2014New Jersey Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Malee","sequence":"additional","affiliation":[{"name":"Children's Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah A.","family":"Pearson","sequence":"additional","affiliation":[{"name":"University of Texas Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon L.","family":"Nichols","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Garvie","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Farley","sequence":"additional","affiliation":[{"name":"University of Maryland School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly L.","family":"Nozyce","sequence":"additional","affiliation":[{"name":"Bronx Lebanon Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Mintz","sequence":"additional","affiliation":[{"name":"The Center for Neurological and Neurodevelopmental Health and the Clinical Research Center of New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige L.","family":"Williams","sequence":"additional","affiliation":[{"name":"Harvard School of Public Health Research"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,11,1]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"15","article-title":"Young people: The centre of the HIV epidemic","volume":"938","author":"Monasch R","year":"2006","unstructured":"Monasch R, , Mahy M. 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