{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:51:52Z","timestamp":1789678312057,"version":"4.0.1"},"reference-count":60,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Patient Care and STDs"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>\n                    This study evaluates the frequency and causes of dolutegravir (DTG) discontinuation along 5 years of follow-up, in both antiretroviral treatment (ART)-naive and experienced people living with HIV (PLWH). This is a prospective multi-center cohort study enrolling PLWH on DTG from July 2014 until November 2020. DTG-durability was investigated using the Kaplan\u2013Meier survival curve. The Cox proportional-hazards model was used for estimating the hazard ratio (HR) of DTG discontinuation for any cause, and for adverse events (AEs). Nine hundred sixty-three PLWH were included, 25.3% were women and 28.0% were ART-naive. Discontinuations for any causes were 10.1 [95% confidence interval (95% CI) 8.9\u201311.5] per 100 person-years, similar in most regimens, with the apparent exception of tenofovir alafenamide\/emtricitabine+DTG (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). In the multivariable Cox regression model, non-Caucasian ethnicity, age \u226550 years, and lower estimated glomerular filtration rate (eGFR) were associated with a higher probability of DTG interruption. The incidence rate of virological failure was 0.4 (95% CI 0.2\u20130.7) per 100 person-years, while the estimated discontinuation rate for AEs was 4.0 (3.2\u20134.9) per 100 person-years. Thirty-four DTG interruptions were due to grade \u22653 events (10 central nervous system, 6 hypersensitivity, 3 renal, 3 myalgia\/asthenia, 3 abdominal pain, 2 gastrointestinal, and 7 other events). People with lower body mass index, age \u226550 years, and lower eGFR were at higher risk of AEs, while dual combinations were protective (HR 0.41 compared with abacavir\/lamivudine\/DTG, 95% CI 0.22\u20130.77). In this prospective observational study, we found high DTG durability and a low rate of virological failures. Dual therapies seemed protective toward AEs and might be considered, when feasible, a suitable option to minimize drug interactions and improve tolerability.\n                  <\/jats:p>","DOI":"10.1089\/apc.2021.0089","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T16:52:58Z","timestamp":1631724778000},"page":"342-353","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Durability of Dolutegravir-Based Regimens: A 5-Year Prospective Observational Study"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6622-6358","authenticated-orcid":false,"given":"Lucia","family":"Taramasso","sequence":"first","affiliation":[{"name":"Infectious Disease Clinic, IRCCS Policlinico San Martino Hospital, Genoa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"De Vito","sequence":"additional","affiliation":[{"name":"Unit of Infectious and Tropical Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Delfina","family":"Ricci","sequence":"additional","affiliation":[{"name":"Fondazione ASIA Onlus, Buccinasco, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Orofino","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, \u201cDivisione A\u201d, Amedeo di Savoia Hospital, Torino, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Squillace","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Menzaghi","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, ASST della Valle Olona, Busto Arsizio Hospital, Busto Arsizio, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Molteni","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, Ospedale A. 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Barresi\u2019, University of Messina, Messina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Sarchi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, SS. Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetto Maurizio","family":"Celesia","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, University of Catania, ARNAS Garibaldi, Catania, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Calza","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. 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