{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:06:26Z","timestamp":1788444386823,"version":"build-2803163510"},"reference-count":44,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Patient Care and STDs"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>\n                    For women in the United States who remain sexually active beyond child-bearing years, susceptibility to HIV infection remains, yet condom use is low. We assessed acceptability of the dapivirine vaginal ring (ring) among 96 postmenopausal US women enrolled in a placebo-controlled multisite phase II trial of the ring, using questionnaires and in-depth interviews. Three quarters of women reported \u201cperfect\u201d adherence (ring never out) over the 3-month trial period. At study exit, the ring was found to be very easy to use by 72%, very comfortable to wear by 65%, and 4% reported it ever interfered with their daily activities. The most common worries among participants at preinitiation had decreased significantly at study exit (e.g., worries about inserting the ring declined from 46% to 6%, discomfort during daily activities from 53% to 3%, ring not staying in place from 48% to 14%, all\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Despite some couples feeling the ring during sex, the ring was perceived as more suitable than condoms for prevention because it was not burdensome to use, did not interfere with erection, and provided (for some) additional vaginal lubrication. The ring is a promising, highly acceptable HIV prevention method that is suitable to the lives of postmenopausal women and their male partners and can provide them with an additional prevention choice.\n                  <\/jats:p>\n                  <jats:p>Clinical Trials Registration: NCT02010593.<\/jats:p>","DOI":"10.1089\/apc.2022.0002","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T10:51:48Z","timestamp":1647341508000},"page":"97-105","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Acceptability of the Dapivirine Vaginal Ring in Postmenopausal US Women"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9805-3132","authenticated-orcid":false,"given":"Mary Kate","family":"Shapley-Quinn","sequence":"first","affiliation":[{"name":"Global Public Health Impact Center, RTI International, Berkeley, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7273-2476","authenticated-orcid":false,"given":"Nicole","family":"Laborde","sequence":"additional","affiliation":[{"name":"Independent Consultant, San Rafael, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Luecke","sequence":"additional","affiliation":[{"name":"Global Public Health Impact Center, RTI International, Berkeley, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Hoesley","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Salata","sequence":"additional","affiliation":[{"name":"University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherri","family":"Johnson","sequence":"additional","affiliation":[{"name":"FHI 360, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalene","family":"Nel","sequence":"additional","affiliation":[{"name":"International Partnership for Microbicides, Silver Spring, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Soto-Torres","sequence":"additional","affiliation":[{"name":"Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice A.","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Pittsburgh\/Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"van der Straten","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for AIDS Prevention Studies, University of California, San Francisco, California, USA."},{"name":"ASTRA Consulting, Kensington, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the MTN-024\/IPM 031 Protocol Team for the Microbicide Trials Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"UNAIDS. Fact sheet 2021: Global HIV Statistics. Available at: https:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/UNAIDS_FactSheet_en.pdf (Last accessed October11 2021)."},{"key":"e_1_3_5_3_2","unstructured":"Centers for Disease Control and Prevention. HIV and older Americans. Available at: https:\/\/www.cdc.gov\/hiv\/group\/age\/olderamericans\/index.html (Last accessed November23 2020)."},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207005"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11930-017-0119-0"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2012.300844"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31823fd215"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2011.34"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2016.0320"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6830.809"},{"key":"e_1_3_5_11_2","unstructured":"U.S. Food & Drug Administration. FDA Approves First Injectable Treatment for HIV Pre-Exposure Prevention. 2020. Available at: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-injectable-treatment-hiv-pre-exposure-prevention (Last accessed January11 2022)."},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.1917"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25298"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz896"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-020-01295-0"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa037"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2017.1286287"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001145"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001160"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2017.0075"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506110"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602046"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(20)30304-0"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(20)30300-3"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25634"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224898"},{"key":"e_1_3_5_27_2","unstructured":"IPM. Dapivirine Ring. Available at: https:\/\/www.ipmglobal.org\/our-work\/our-products\/dapivirine-ring (Last accessed November18 2021)."},{"key":"e_1_3_5_28_2","unstructured":"National Institutes of Health. Vaginal ring for HIV prevention receives positive opinion from European regulator. Available at: https:\/\/www.nih.gov\/news-events\/news-releases\/vaginal-ring-hiv-prevention-receives-positive-opinion-european-regulator (Last accessed November23 2020)."},{"key":"e_1_3_5_29_2","unstructured":"World Health Organization. WHO recommends the dapivirine vaginal ring as a new choice for HIV prevention for women at substantial risk of HIV infection. Available at: https:\/\/www.who.int\/news\/item\/26-01-2021-who-recommends-the-dapivirine-vaginal-ring-as-a-new-choice-for-hiv-prevention-for-women-at-substantial-risk-of-hiv-infection (Last accessed October11 2021)."},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy654"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-2-45"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e3283590632"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002028"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147743"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-016-1299-8"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-021-03231-x"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2021.10.001"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2019.0242"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/0162243910366135"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.3109\/13625187.2012.700744"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-020-03119-2"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-019-02521-9"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-017-1977-1"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3181cd70c2"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002253"}],"container-title":["AIDS Patient Care and STDs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/apc.2022.0002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/apc.2022.0002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/apc.2022.0002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:04:28Z","timestamp":1777399468000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/apc.2022.0002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1089\/apc.2022.0002"],"URL":"https:\/\/doi.org\/10.1089\/apc.2022.0002","relation":{},"ISSN":["1087-2914","1557-7449"],"issn-type":[{"value":"1087-2914","type":"print"},{"value":"1557-7449","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3]]}}}